All Phenotypes Sema3f<tm1Mom> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sema3f^tm1Mom
targeted mutation 1, Peter Mombaerts
MGI:3758889

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Sema3f^tm1Mom/Sema3f^tm1Mom Vmn1r49^tm1Mom/Vmn1r49^tm1Mom	involves: 129P2/OlaHsd * C57BL/6J	MGI:3760745
cx2	Sema3f^tm1Mom/Sema3f⁺ Vmn1r49^tm1Mom/Vmn1r49^tm1Mom	involves: 129P2/OlaHsd * C57BL/6J	MGI:3760746
cx3	Gucy2d^tm1Mom/Gucy2d^tm1Mom Sema3f^tm1Mom/Sema3f^tm1Mom	involves: 129P2/OlaHsd * C57BL/6J	MGI:3760748

Allelic Composition	Sema3f^tm1Mom/Sema3f^tm1Mom Vmn1r49^tm1Mom/Vmn1r49^tm1Mom
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema3f^tm1Mom mutation (1 available); any Sema3f mutation (41 available)
Vmn1r49^tm1Mom mutation (1 available); any Vmn1r49 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal accessory olfactory bulb morphology ( J:125485 )

• Npr2+ axons erroneously project into the posterior accessory olfactory bulb

• V1rb2+ axons form glomeruli in the posterior accessory olfactory bulb unlike in wild-type mice

Allelic Composition	Sema3f^tm1Mom/Sema3f⁺ Vmn1r49^tm1Mom/Vmn1r49^tm1Mom
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal accessory olfactory bulb morphology ( J:125485 )

• in 18.2% of mice, exhibit misprojections of V1rb2+ axons in the accessory olfactory bulb

Allelic Composition	Gucy2d^tm1Mom/Gucy2d^tm1Mom Sema3f^tm1Mom/Sema3f^tm1Mom
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gucy2d^tm1Mom mutation (1 available); any Gucy2d mutation (42 available)
Sema3f^tm1Mom mutation (1 available); any Sema3f mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory bulb morphology ( J:125485 )

• authors state that mice exhibit the same defects as observed in Gucy2d^tm1Mom Nrp2^tm1.2Mom homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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