All Phenotypes Gucy2d<tm1Mom> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gucy2d^tm1Mom
targeted mutation 1, Peter Mombaerts
MGI:3758883

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Gucy2d^tm1Mom/Gucy2d^tm1Mom Nrp2^tm1.2Mom/Nrp2^tm1.2Mom	involves: 129P2/OlaHsd * C57BL/6J	MGI:3760743
cx2	Gucy2d^tm1Mom/Gucy2d^tm1Mom Sema3f^tm1Mom/Sema3f^tm1Mom	involves: 129P2/OlaHsd * C57BL/6J	MGI:3760748
cx3	Gucy2d^tm1Mom/Gucy2d^tm1Mom Sema3b^tm1Mom/Sema3b^tm1Mom	involves: 129P2/OlaHsd * C57BL/6J	MGI:3760749
cx4	Gucy2d^tm1Mom/Gucy2d^tm1Mom Sema3c^tm1.1Jra/Sema3c^tm1.1Jra	involves: 129P2/OlaHsd * C57BL/6J	MGI:3760750

Allelic Composition	Gucy2d^tm1Mom/Gucy2d^tm1Mom Nrp2^tm1.2Mom/Nrp2^tm1.2Mom
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gucy2d^tm1Mom mutation (1 available); any Gucy2d mutation (42 available)
Nrp2^tm1.2Mom mutation (1 available); any Nrp2 mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory bulb morphology ( J:125485 )

• guanylate cyclase- D (GC-D) positive glomeruli fan out more than in wild-type mice and glomeruli form at inappropriate locations

• many GC-D+ glomeruli scatter ectopically across the main olfactory bulb up to the rostral tip

• fewer GC-D+ glomeruli are found in the necklace compared to in wild-type mice

• the number of GC-D+ glomeruli is increased compared to in wild-type mice

• Npr2+ axons erroneously project into the posterior accessory olfactory bulb

Allelic Composition	Gucy2d^tm1Mom/Gucy2d^tm1Mom Sema3f^tm1Mom/Sema3f^tm1Mom
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gucy2d^tm1Mom mutation (1 available); any Gucy2d mutation (42 available)
Sema3f^tm1Mom mutation (1 available); any Sema3f mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory bulb morphology ( J:125485 )

• authors state that mice exhibit the same defects as observed in Gucy2d^tm1Mom Nrp2^tm1.2Mom homozygotes

Allelic Composition	Gucy2d^tm1Mom/Gucy2d^tm1Mom Sema3b^tm1Mom/Sema3b^tm1Mom
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gucy2d^tm1Mom mutation (1 available); any Gucy2d mutation (42 available)
Sema3b^tm1Mom mutation (1 available); any Sema3b mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:125485 )

N	• olfactory bulb innervation is normal

Allelic Composition	Gucy2d^tm1Mom/Gucy2d^tm1Mom Sema3c^tm1.1Jra/Sema3c^tm1.1Jra
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gucy2d^tm1Mom mutation (1 available); any Gucy2d mutation (42 available)
Sema3c^tm1.1Jra mutation (0 available); any Sema3c mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:125485 )

N	• olfactory bulb innervation is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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