Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Comptm1Mbri mutation
(0 available);
any
Comp mutation
(36 available)
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muscle
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• at 3 weeks, 33% of muscle fibers exhibit centrally localized nuclei unlike in wild-type mice
• centrally located nuclei are present at myotendinous junction and around the perimysium unlike in wild-type mice
• at 6 weeks, the number of muscle fibers with centrally located nuclei is more than 2.5-fold greater than in wild-type mice
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• at 3 and 9 weeks, the distribution of collagen fibril diameters in the Achilles tendon is altered compared to in wild-type mice
• at 3 weeks, the total number of collage fibers in the Achilles tendon are reduced compared to in wild-type mice
• at 3 weeks, more fused or bifurcating and thinner collagen fibrils are found in the Achilles tendon compared to in wild-type mice
• however, endoplasmic reticulum stress and apoptosis is not increased in tenocytes
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• the Achilles tendon is more lax than wild-type tendons in biomechanical testing
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• at 3 weeks, mice exhibit a 12.6% decrease in grip release strength compared with wild-type mice
• at 9 weeks, maximum grip strength and release force is lower than in wild-type mice
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behavior/neurological
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• at 9 weeks, maximum grip strength and release force is lower than in wild-type mice
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skeleton
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• at 3 and 9 weeks, the distribution of collagen fibril diameters in the Achilles tendon is altered compared to in wild-type mice
• at 3 weeks, the total number of collage fibers in the Achilles tendon are reduced compared to in wild-type mice
• at 3 weeks, more fused or bifurcating and thinner collagen fibrils are found in the Achilles tendon compared to in wild-type mice
• however, endoplasmic reticulum stress and apoptosis is not increased in tenocytes
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• the Achilles tendon is more lax than wild-type tendons in biomechanical testing
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Comptm1Mbri mutation
(0 available);
any
Comp mutation
(36 available)
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cellular
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• the apoptosis rates for chondrocytes in the growth plate, proliferative zone and resting zone are increased by 3.3-fold, 12-fold and 2.5-fold, respectively, relative to apoptosis rates in wild-type mice
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• proliferation of chondrocyte in the proliferative zone is decreased as indicated by a 24% reduction in bromodeoxyuridine-labelled chondrocytes relative to in wild-type mice
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skeleton
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• the apoptosis rates for chondrocytes in the growth plate, proliferative zone and resting zone are increased by 3.3-fold, 12-fold and 2.5-fold, respectively, relative to apoptosis rates in wild-type mice
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• proliferation of chondrocyte in the proliferative zone is decreased as indicated by a 24% reduction in bromodeoxyuridine-labelled chondrocytes relative to in wild-type mice
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• by 16 months, mice develop degenerative joint disease with loss of cartilage from the articular surface
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• mice exhibit hip dysplasia characterized by the tuberosity of the ischium protruding from the pelvic region at an angle of greater than 15 degrees
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• by 9 weeks male mice tibia are 4% shorter than in wild-type mice
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• chondrocytes alignment in the proliferative zone is disrupted from 2 weeks of age
• chondrocyte columns are reduced in number and in some cases terminate prematurely with a corresponding increase in the amount of space between individual columns
• at 3 weeks, proliferative zones are enlarged by greater than 15%
• chondrocytes within the proliferative zone are disorganized, irregularly shaped, heterogeneous and not aligned within the chondrons
• fibrillar material in the interterritorial matrix is more abundant and better defined than in heterozygotes and wild-type mice
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• mice exhibit hip dysplasia characterized by the tuberosity of the ischium protruding from the pelvic region at an angle of greater than 15 degrees
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• chondrocytes exhibit a mild rough endoplasmic reticulum stress as determined by expression and activity levels of Hspa5, Eif2s1, Ddit3, Atf6, Casp12, and Bcl2
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growth/size/body
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• by 9 weeks male mice are 6% lighter than wild-type mice and female mice are likewise lighter than wild-type mice
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• by 9 weeks mice develop short limb dwarfism
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immune system
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• by 16 months, mice develop degenerative joint disease with loss of cartilage from the articular surface
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limbs/digits/tail
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• mice exhibit hip dysplasia characterized by the tuberosity of the ischium protruding from the pelvic region at an angle of greater than 15 degrees
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• by 9 weeks male mice tibia are 4% shorter than in wild-type mice
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• by 9 weeks mice develop short limb dwarfism
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Allelic Composition |
Comptm1Mbri/Comp+
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Genetic Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Comptm1Mbri mutation
(0 available);
any
Comp mutation
(36 available)
|
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cellular
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• the apoptosis rates for chondrocytes in the growth plate, proliferative zone and resting zone are increased by 1.8-fold and 9.8-fold, respectively, relative to apoptosis rates in wild-type mice
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• proliferation of chondrocyte in the proliferative zone is decreased as indicated by a 12% reduction in bromodeoxyuridine-labelled chondrocytes relative to in wild-type mice
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skeleton
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• the apoptosis rates for chondrocytes in the growth plate, proliferative zone and resting zone are increased by 1.8-fold and 9.8-fold, respectively, relative to apoptosis rates in wild-type mice
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• proliferation of chondrocyte in the proliferative zone is decreased as indicated by a 12% reduction in bromodeoxyuridine-labelled chondrocytes relative to in wild-type mice
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• by 9 weeks male mice tibia are 2% shorter than in wild-type mice
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• the interterritorial matrix appears to contain less proteoglycan-like amorphous material than in wild-type mice making the collagen fibrils more prominent
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• mice exhibit mild pelvic deformation
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limbs/digits/tail
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• by 9 weeks male mice tibia are 2% shorter than in wild-type mice
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