Phenotypes associated with this allele

• Allele Symbol: Ticam2^tm1Btlr
• Allele Name: targeted mutation 1, Bruce Beutler
• Allele ID: MGI:3722129
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ticam2^tm1Btlr/Ticam2^tm1Btlr	C57BL/6J-Ticam2^tm1Btlr	MGI:3783291

Genotype
MGI:3783291

hm1

• Allelic Composition: Ticam2^tm1Btlr/Ticam2^tm1Btlr
• Genetic Background: C57BL/6J-Ticam2^tm1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal interferon secretion ( J:133619 )

• peritoneal macrophages from mice homozygous for this mutation produce no type I interferon (IFN) in response to lipopolysaccharide (LPS), a Toll-like receptor (TLR) 4 ligand

• homozygous mutant macrophages produce normal levels of type I INF in response to poly I:C, a TLR3 ligand

decreased tumor necrosis factor secretion ( J:133619 )

• homozygous mutant peritoneal macrophages produce little tumor necrosis factor (TNF) alpha in response to the TLR4 ligand LPS