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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nmur2tm1Rtor
targeted mutation 1, Richard Torres
MGI:3722114
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nmur2tm1Rtor/Nmur2tm1Rtor involves: 129S1/Sv * C57BL/6NTac MGI:3722691
cx2
Nmur1tm1Rtor/Nmur1tm1Rtor
Nmur2tm1Rtor/Nmur2tm1Rtor
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6NCr * C57BL/6NTac MGI:3722690


Genotype
MGI:3722691
hm1
Allelic
Composition
Nmur2tm1Rtor/Nmur2tm1Rtor
Genetic
Background
involves: 129S1/Sv * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nmur2tm1Rtor mutation (0 available); any Nmur2 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• following injection of capsaicin or formalin in the hindpaw, mice display a 39% and 38% reduction, respectively, in targeted chronic pain behavior (licking)
• mice exhibit attenuation of hyperalgesia induced by intradermal injection of capsaicin and exposure to a hot plate after 90 minutes compared to wild-type mice that had a 53% reduction in latency when compared to the 15 minute time point
• however, response to injection of complete Freund's adjuvant is the same as in wild-type mice
• using a hot plate test, latency to respond is increased relative to in wild-type mice

integument
• following injection of capsaicin or formalin in the hindpaw, mice display a 39% and 38% reduction, respectively, in targeted chronic pain behavior (licking)
• mice exhibit attenuation of hyperalgesia induced by intradermal injection of capsaicin and exposure to a hot plate after 90 minutes compared to wild-type mice that had a 53% reduction in latency when compared to the 15 minute time point
• however, response to injection of complete Freund's adjuvant is the same as in wild-type mice
• using a hot plate test, latency to respond is increased relative to in wild-type mice




Genotype
MGI:3722690
cx2
Allelic
Composition
Nmur1tm1Rtor/Nmur1tm1Rtor
Nmur2tm1Rtor/Nmur2tm1Rtor
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6NCr * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nmur1tm1Rtor mutation (0 available); any Nmur1 mutation (11 available)
Nmur2tm1Rtor mutation (0 available); any Nmur2 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• latency to respond to the hot plate test is increased relative to in wild-type mice but similar to in Nmur2tm1Rtor homozygotes

integument
• latency to respond to the hot plate test is increased relative to in wild-type mice but similar to in Nmur2tm1Rtor homozygotes





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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory