Phenotypes associated with this allele

• Allele Symbol: Tpo^tee-2J
• Allele Name: teeny 2 Jackson
• Allele ID: MGI:3721538
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tpo^tee-2J/Tpo^tee-2J	B6.Cg-Tpo^tee-2J H2^g7/GrsrJ	MGI:5523799
hm2	Tpo^tee-2J/Tpo^tee-2J	C3.B6(NOD)-Tpo^tee-2J/Kjn	MGI:5523800

Genotype
MGI:5523799

hm1

• Allelic Composition: Tpo^tee-2J/Tpo^tee-2J
• Genetic Background: B6.Cg-Tpo^tee-2J H2^g7/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

proportional dwarf ( J:202956 )

• distinctly smaller size is evident by 1 week of age and persists throughout the life of the homozygote with the average body weight between 6 and 7 weeks of only 8.5 grams

hearing/vestibular/ear

delayed inner ear development ( J:202956 )

• cochlear development is delayed such that at 7 days of age the inner sulcus has not formed, and the thickened tectorial membrane remains attached to large columnar epithelial cells, at 14 days of age the cochlea resembles that of a normal cochlea at 7 days of age with the inner sulcus formed and the tunnel of Corti and space of Nuel only beginning to form, and at 1 month of age the cochlea resembles a mature cochlea except the tectorial membrane remains abnormally thickened

abnormal cochlea morphology ( J:202956 )

abnormal tectorial membrane morphology ( J:202956 )

• delayed in its correct changes in development the tectorial membrane remains thickened

increased or absent threshold for auditory brainstem response ( J:202956 )

• Background Sensitivity: ABR thresholds to broadband clicks and to 8, 16, and 32 kHz pure tone stimuli assessed at 1.5 months of age are highly elevated indicative of a 60-70 dB hearing loss, which is not statistically different from the hearing loss found in teeny homozyogtes on a C57BL/6J background, but is statistically more severe than that of teeny 2 Jackson homozygotes on a C3H/HeJ background

endocrine/exocrine glands

abnormal thyroid gland morphology ( J:202956 )

• the thyroid glands of homozygotes are dysplastic with poorly developed follicles and hyperproliferation of epithelial cells

abnormal thyroid follicle morphology ( J:202956 )

• poorly developed follicles

abnormal thyroid gland development ( J:202956 )

small thyroid gland ( J:202956 )

• consistent with a lack of thyroid hormone synthesis

abnormal thyroid gland physiology ( J:202956 )

decreased activity of thyroid gland ( J:202956 )

• serum T4 is below the level of detection, less than 0.4 ug/dl, at 5 to 8 weeks of age

Genotype
MGI:5523800

hm2

• Allelic Composition: Tpo^tee-2J/Tpo^tee-2J
• Genetic Background: C3.B6(NOD)-Tpo^tee-2J/Kjn

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:202956 )

• Background Sensitivity: ABR thresholds to broadband clicks and to 8, 16, and 32 kHz pure tone stimuli assessed at 1.5 months of age are highly elevated indicative of a hearing deficit, which is slightly but significantly less severe than the hearing deficit found in teeny or teeny 2 Jackson homozygotes on a C57BL/6J background

growth/size/body

proportional dwarf ( J:202956 )

• distinctly smaller size is evident by 1 week of age and persists throughout the life of the homozygote