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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		F12tm1Pbfd
targeted mutation 1, Peter Burfiend
MGI:3720935
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		F12tm1Pbfd/F12tm1Pbfd B6.Cg-F12tm1Pbfd MGI:3721103
hm2
 		F12tm1Pbfd/F12tm1Pbfd either: 129X1/SvJ-F12tm1Pbfd or (involves: 129X1/SvJ * C57BL/6J) MGI:3721095


Genotype
MGI:3721103
hm1
Allelic
Composition		 F12tm1Pbfd/F12tm1Pbfd
Genetic
Background		 B6.Cg-F12tm1Pbfd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F12tm1Pbfd mutation (0 available); any F12 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal response to CNS ischemic injury ( J:123758 )
• following transient cerebral ischemia, fibrin accumulation is less than in wild-type mice
• following transient cerebral ischemia, ischemic neurodegeneration associated with occlusions of vessel lumina is less severe than in wild-type mice and fewer occlusions are detected
decreased cerebral infarct size ( J:123758 )
• following transient cerebral ischemia, infarct size is reduced to less than 50% of that in wild-type mice and results in improved motor coordination and function relative to wild-type mice following injury

homeostasis/metabolism
abnormal response to CNS ischemic injury ( J:123758 )
• following transient cerebral ischemia, fibrin accumulation is less than in wild-type mice
• following transient cerebral ischemia, ischemic neurodegeneration associated with occlusions of vessel lumina is less severe than in wild-type mice and fewer occlusions are detected
decreased cerebral infarct size ( J:123758 )
• following transient cerebral ischemia, infarct size is reduced to less than 50% of that in wild-type mice and results in improved motor coordination and function relative to wild-type mice following injury

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
factor XII deficiency DOID:2231 OMIM:234000
 J:100529




Genotype
MGI:3721095
hm2
Allelic
Composition		 F12tm1Pbfd/F12tm1Pbfd
Genetic
Background		 either: 129X1/SvJ-F12tm1Pbfd or (involves: 129X1/SvJ * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F12tm1Pbfd mutation (0 available); any F12 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:124154 )
• mice are fertile and viable with no detected abnormalities in the lungs, kidney, liver, small bowel, heart and spleen




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory