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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Thy1-MAPT)2Vln
transgene insertion 2, Fred Van Leuven
MGI:3720114
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(GSK3B*S9A)1Vln/0
Tg(Thy1-MAPT)2Vln/Tg(Thy1-MAPT)2Vln
involves: FVB MGI:3722102
tg2
Tg(Thy1-MAPT)2Vln/Tg(Thy1-MAPT)2Vln involves: FVB MGI:3720208


Genotype
MGI:3722102
cx1
Allelic
Composition
Tg(GSK3B*S9A)1Vln/0
Tg(Thy1-MAPT)2Vln/Tg(Thy1-MAPT)2Vln
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice show equal performance to wild-type in the hanging grid test and forced swim test, and show almost no impairment of the righting reflex (J:100971)
• mice show equal performance to wild-type in the hanging grid test and forced swim test, and show almost no impairment of the righting reflex (J:100971)
• double mutants are unable to remain on the rotating rod (J:100971)
• double mutants are unable to remain on the rotating rod (J:100971)

nervous system
• in 3-month old mice, dilated axons are observed, but numbers are reduced ~10-fold compared to Tg(Thy1-MAPT)2Vln homozygotes in spinal cord and cerebral cortex (J:100971)
• axonal dystrophic changes are dramatically reduced in mice expressing both transgenes (J:100971)
• in 3-month old mice, dilated axons are observed, but numbers are reduced ~10-fold compared to Tg(Thy1-MAPT)2Vln homozygotes in spinal cord and cerebral cortex (J:100971)
• axonal dystrophic changes are dramatically reduced in mice expressing both transgenes (J:100971)

muscle
N
• quadriceps is normal and devoid of any muscle wasting (J:100971)
• quadriceps is normal and devoid of any muscle wasting (J:100971)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:100971




Genotype
MGI:3720208
tg2
Allelic
Composition
Tg(Thy1-MAPT)2Vln/Tg(Thy1-MAPT)2Vln
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• when lifted by tail, homozygotes flex the hind limbs, in contrast to wild-type which extend legs (J:100972)
• when lifted by tail, homozygotes flex the hind limbs, in contrast to wild-type which extend legs (J:100972)
• compared to wild-type mice, mutants are 90 times more likely to fall off of a rotating rod in a rotarod test; (J:100972)
• compared to wild-type mice, mutants are 90 times more likely to fall off of a rotating rod in a rotarod test; (J:100972)

muscle

nervous system
• in 3 month old mice, dilated axons are detected in the spinal cord and cerebral cortex, although numbers are fewer than in Tg(Thy1-MAPT)1Vln homozygotes (J:100971)
• cytoskeletons of dilated axons are disrupted, with numerous randomly oriented microtubules engirdling accumulations of pleomorphic vesicles, dense-cored vesicles, and smooth endoplasmic reticulum; ratio of microtubules to neurofilaments in dilated axons is high relative to normal axons (J:100971)
• grouping of atrophic fibers and fascicular atrophy are observed (J:100971)
• in 3 month old mice, dilated axons are detected in the spinal cord and cerebral cortex, although numbers are fewer than in Tg(Thy1-MAPT)1Vln homozygotes (J:100971)
• cytoskeletons of dilated axons are disrupted, with numerous randomly oriented microtubules engirdling accumulations of pleomorphic vesicles, dense-cored vesicles, and smooth endoplasmic reticulum; ratio of microtubules to neurofilaments in dilated axons is high relative to normal axons (J:100971)
• grouping of atrophic fibers and fascicular atrophy are observed (J:100971)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:100971 , J:100972





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory