Mouse Genome Informatics
cx1
    Tg(GSK3B*S9A)1Vln/0
Tg(Thy1-MAPT)2Vln/Tg(Thy1-MAPT)2Vln

involves: FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
N
• mice show equal performance to wild-type in the hanging grid test and forced swim test, and show almost no impairment of the righting reflex (J:100971)
• double mutants are unable to remain on the rotating rod

nervous system
• in 3-month old mice, dilated axons are observed, but numbers are reduced ~10-fold compared to Tg(Thy1-MAPT)2Vln homozygotes in spinal cord and cerebral cortex
• axonal dystrophic changes are dramatically reduced in mice expressing both transgenes

muscle
N
• quadriceps is normal and devoid of any muscle wasting (J:100971)

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:100971


Mouse Genome Informatics
tg2
    Tg(Thy1-MAPT)2Vln/Tg(Thy1-MAPT)2Vln
involves: FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• when lifted by tail, homozygotes flex the hind limbs, in contrast to wild-type which extend legs
• compared to wild-type mice, mutants are 90 times more likely to fall off of a rotating rod in a rotarod test; (J:100972)

muscle

nervous system
• in 3 month old mice, dilated axons are detected in the spinal cord and cerebral cortex, although numbers are fewer than in Tg(Thy1-MAPT)1Vln homozygotes
• cytoskeletons of dilated axons are disrupted, with numerous randomly oriented microtubules engirdling accumulations of pleomorphic vesicles, dense-cored vesicles, and smooth endoplasmic reticulum; ratio of microtubules to neurofilaments in dilated axons is high relative to normal axons
• grouping of atrophic fibers and fascicular atrophy are observed

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:100971 , J:100972