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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Bsxtm2Aoh
targeted mutation 2, Akihira Ohtoshi
MGI:3719245
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Bsxtm2Aoh/Bsxtm2Aoh either: 129S4/SvJae-Bsxtm2Aoh or (involves: 129S4/SvJae * C57BL/6) MGI:3720334


Genotype
MGI:3720334
hm1
Allelic
Composition
Bsxtm2Aoh/Bsxtm2Aoh
Genetic
Background
either: 129S4/SvJae-Bsxtm2Aoh or (involves: 129S4/SvJae * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bsxtm2Aoh mutation (0 available); any Bsx mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• mice with homozygous mothers fail to reach adulthood
• mice with homozygous mothers exhibit poor growth due to malnutrition

endocrine/exocrine glands
• precocious involution of the lactating mammary gland occurs
• females exhibit increased apoptosis in the postpartum mammary gland relative to wild-type mice
• on postpartum day 1, females have less alveoli
• mice with homozygous mothers exhibit poor growth due to malnutrition
• females exhibit increased apoptosis in the postpartum mammary gland relative to wild-type mice

growth/size/body
• mice are proportionally smaller than wild-type mice
• after 2 weeks mice weight less than wild-type mice

integument
• precocious involution of the lactating mammary gland occurs
• females exhibit increased apoptosis in the postpartum mammary gland relative to wild-type mice
• on postpartum day 1, females have less alveoli
• mice with homozygous mothers exhibit poor growth due to malnutrition
• females exhibit increased apoptosis in the postpartum mammary gland relative to wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory