Phenotypes associated with this allele

• Allele Symbol: Ramp2^tm1Kmca
• Allele Name: targeted mutation 1, Kathleen Caron
• Allele ID: MGI:3718497
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ramp2^tm1Kmca/Ramp2^tm1Kmca	involves: 129S6/SvEvTac	MGI:3718781
hm2	Ramp2^tm1Kmca/Ramp2^tm1Kmca	involves: 129S6/SvEvTac * C57BL/6	MGI:3772942
ht3	Ramp2^tm1Kmca/Ramp2^+	involves: 129S6/SvEvTac	MGI:3718783

Genotype
MGI:3718781

hm1

• Allelic Composition: Ramp2^tm1Kmca/Ramp2^tm1Kmca
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:123382 )

• no mice are born alive

Genotype
MGI:3772942

hm2

• Allelic Composition: Ramp2^tm1Kmca/Ramp2^tm1Kmca
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Lymphatic endothelial cells of Ramp2^tm1Kmca/Ramp2^tm1Kmca mice are thin

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:130930 )

• mice die 1 to 2 days after developing edema

cardiovascular system

abnormal aorta smooth muscle morphology ( J:130930 )

• the vascular smooth muscle lining of the aorta is decreased

small heart ( J:130930 )

abnormal heart right ventricle morphology ( J:130930 )

• the thickness of the compact zone of the right ventricle is decreased compared to in wild-type mice

immune system

abnormal lymph organ development ( J:130930 )

• at E13.5, the jugular lymph sac is smaller than in wild-type mice despite lymphedema

• lymph endothelial cells are thinner and exhibit reduced proliferation compared to lymphatic endothelial cells in wild-type mice

abnormal lymphatic vessel morphology ( J:130930 )

• mice lack a jugular lymphatic trunk

• however, lymphatics vasculature displays normal ultrastructure

homeostasis/metabolism

edema ( J:130930 )

• at E14.5, mice interstitial exhibit edema without hemorrhage

lymphedema ( J:130930 )

muscle

abnormal aorta smooth muscle morphology ( J:130930 )

• the vascular smooth muscle lining of the aorta is decreased

Genotype
MGI:3718783

ht3

• Allelic Composition: Ramp2^tm1Kmca/Ramp2⁺
• Genetic Background: involves: 129S6/SvEvTac

reproductive system

decreased litter size ( J:123382 )

• mice yield an average of 2.1 pups per litter compared to an expected litter of 4.5 pups when the lethality of homozygous embryos is taken into account