Phenotypes associated with this allele

• Allele Symbol: Hdac2^tm1.2Eno
• Allele Name: targeted mutation 1.2, Eric N Olson
• Allele ID: MGI:3717930
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hdac2^tm1.2Eno/Hdac2^tm1.2Eno	involves: 129S/SvEv * C57BL/6 * CD-1	MGI:3718386

Genotype
MGI:3718386

hm1

• Allelic Composition: Hdac2^tm1.2Eno/Hdac2^tm1.2Eno
• Genetic Background: involves: 129S/SvEv * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:123173 )

• all mice die within 24 hours of birth

cardiovascular system

thick interventricular septum ( J:123173 )

• all mice have a thickened interventricular septum

abnormal heart right ventricle morphology ( J:123173 )

• some neonates have almost a complete loss of the right ventricle lumen

• some mice have a right ventricle that is completely dorsal to the left ventricle

abnormal fetal cardiomyocyte proliferation ( J:123173 )

• proliferation is 3-fold greater than in wild-type hearts

decreased heart rate ( J:123173 )

• at day 1, heart rate is decreased to 152+/-14 beats per minute compared to 235+/-20 beats per minute in wild-type mice

increased cardiomyocyte apoptosis ( J:123173 )

homeostasis/metabolism

cyanosis ( J:123173 )

• all mice are cyanotic at birth

muscle

abnormal fetal cardiomyocyte proliferation ( J:123173 )

• proliferation is 3-fold greater than in wild-type hearts

increased cardiomyocyte apoptosis ( J:123173 )

cellular

abnormal fetal cardiomyocyte proliferation ( J:123173 )

• proliferation is 3-fold greater than in wild-type hearts

increased cardiomyocyte apoptosis ( J:123173 )