Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation
(3 available)
Tg(Eno2-PTGS2)32Pasi mutation
(0 available)
Tg(PSEN1)5Dbo mutation
(1 available)
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nervous system
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N |
• no differences in neuron number in cingulate cortex relative to wild-type
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• immunoreactive amyloid beta deposits are observed in the cingulate cortex in 12 month-old triple transgenic mice; deposits are most evident in gray matter of cingulare and enthorhinal cortex, and to lesser extent in non-neuronal layers of the hippocampal formation
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• within 10 minutes of kainic acid infusion, vigorous status epilepticus leads to death in transgenic animals whereas no wild-type mice die after kainic acid treatment
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behavior/neurological
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• intensity of kainic acid-induced seizures is elevated in transgenic mice relative to wild-type
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• severe seizures in kainic acid-treated mice are associated with generalized tonic-clonic seizures with wild seizure jumps, while wild-type mice do not show any myoclonic twitches
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nervous system
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N |
• no amyloid beta deposits are observed in transgenic mouse brains
• no differences in neuron number in cingulate cortex relative to wild-type
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• intensity of kainic acid-induced seizures is elevated in transgenic mice relative to wild-type
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• severe seizures in kainic acid-treated mice are associated with generalized tonic-clonic seizures with wild seizure jumps, while wild-type mice do not show any myoclonic twitches
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• PTGS2 overexpression in neurons potentiates amyloid beta-mediated neuronal apoptotic damage in cortico-hippocampal cultures
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• in cultured cortico-hippocampal neurons, exposure to glutamate results in 46% impairment of redox activity compared to 31.2% in control neurons, indicating potentiation of excitotoxicity in vitro
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homeostasis/metabolism
cellular
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• in cultured cortico-hippocampal neurons, exposure to glutamate results in 46% impairment of redox activity compared to 31.2% in control neurons, indicating potentiation of excitotoxicity in vitro
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Analysis Tools