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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Ckm-DGAT2)10Far
transgene insertion 10, Bob Farese
MGI:3717406
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Ckm-DGAT2)10Far/0 involves: C57BL/6NHsd MGI:3769441


Genotype
MGI:3769441
tg1
Allelic
Composition
Tg(Ckm-DGAT2)10Far/0
Genetic
Background
involves: C57BL/6NHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ckm-DGAT2)10Far mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• basal uptake of 2-deoxyglucose in glycolytic and oxidative muscle trend higher in transgenic mice compared to wild-type
• tolerance is impaired at 15, 30, and 60 minutes after glucose challenge in 3-month old males
• in response to insulin, 2-deoxyglucose uptake is impaired in glycolytic muscle, while uptake is stimulated ~2-fold in wild-type glycolytic muscle by insulin
• 3-month old male mice show impaired insulin tolerance with higher glucose levels 60 minutes after insulin injection compared to wild-type
• at 3 months in males, diglyceride levels are 42% lower in glycolytic muscle compared to wild-type; ceramide levels are 63% higher and some saturated acyl CoA species are elevated also whereas levels in oxidative muscle are similar in transgenic and wild-type mice
• by 6 months of age, lipid content in glycolytic muscle increase to similar levels in both genotypes
• in 3 month-old male mice, transgene expression increases triglyceride level in glycolytic muscle 1.8-fold, while levels in oxidative muscle, white adipose tissue and liver are similar to wild-type levels
• by 6 months of age, triglyceride content in glycolytic muscle increase to similar levels in both genotypes





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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory