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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cxadrtm1.1Mds
targeted mutation 1.1, Michael D Schneider
MGI:3711226
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cxadrtm1.1Mds/Cxadrtm1.1Mds involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J MGI:3711500
cn2
Cxadrtm1Mds/Cxadrtm1.1Mds
Tg(Tnnt2-cre)5Blh/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:3711513
cn3
Cxadrtm1Mds/Cxadrtm1.1Mds
Tg(Myh6-cre)2182Mds/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:3711512


Genotype
MGI:3711500
hm1
Allelic
Composition
Cxadrtm1.1Mds/Cxadrtm1.1Mds
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxadrtm1.1Mds mutation (0 available); any Cxadr mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all homozygous embryos are dead or undergoing resorption at E12.5 and later times; only one homozygote was identified among living animals at 4 weeks of age

embryogenesis
N
• yolk sac and yolk sac vessels appear normal

cardiovascular system
N
• no definite abnormalities are seen in endocardial cushions, right ventricular wall, right ventricular outflow tract, or other derivatives of the secondary hear field
• at E10.5 and E11.5, engorgement of the cardinal veins is apparent, suggesting cardiac dysfunction
• hyperplasia of proximal heart tube is seen at E10.5
• many embryos show moderate thickening of the atrial myocardium
• junctions between left ventricular cardiomyocytes are abnormal; cells have short membrane contact sites while controls show long stretches of membrane contacts with electron density
• junctions between epicardial and endocardial cells appear normal
• myofilament bundles are thinner than in wild-type and appear less compact
• thickened left ventricle is result of increased cell numbers
• at E10.5 and 11.5, null embryos can be identified by prominence of the left ventricular silhouette
• left ventricular wall is abnormally thickened, with partial obliteration of the ventricular lumen
• proliferation rate of left ventricular cardiomyocytes is twice that in wild-type hearts

muscle
• junctions between left ventricular cardiomyocytes are abnormal; cells have short membrane contact sites while controls show long stretches of membrane contacts with electron density
• junctions between epicardial and endocardial cells appear normal
• myofilament bundles are thinner than in wild-type and appear less compact
• proliferation rate of left ventricular cardiomyocytes is twice that in wild-type hearts

cellular
• proliferation rate of left ventricular cardiomyocytes is twice that in wild-type hearts




Genotype
MGI:3711513
cn2
Allelic
Composition
Cxadrtm1Mds/Cxadrtm1.1Mds
Tg(Tnnt2-cre)5Blh/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxadrtm1.1Mds mutation (0 available); any Cxadr mutation (6 available)
Cxadrtm1Mds mutation (0 available); any Cxadr mutation (6 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no live conditional null mice are found at 4 weeks after birth; embryos at E10.5; mice display identical phenotype to Cxadrtm1.1Mds homozygotes

cardiovascular system
• at E10.5, engorgement of the cardinal veins is apparent
• hyperplasia of proximal heart tube is seen at E10.5
• sinuatrial valves located at junction between sinus venosus and atrium in wild-type embryos, are absent




Genotype
MGI:3711512
cn3
Allelic
Composition
Cxadrtm1Mds/Cxadrtm1.1Mds
Tg(Myh6-cre)2182Mds/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxadrtm1.1Mds mutation (0 available); any Cxadr mutation (6 available)
Cxadrtm1Mds mutation (0 available); any Cxadr mutation (6 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• many conditional null mice are born alive and survive to adulthood (20/102)

cardiovascular system
• sinuatrial valves show mild abnormalities in embryos, with only 1 embryo showing absence or attenuation comparable to constitutive null mice
• embryos show only mild or no abnormal ventricular thickening with little or no increase in proliferating cells





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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory