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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nol3tm1Rvh
targeted mutation 1, Rudiger von Harsdorf
MGI:3711185
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nol3tm1Rvh/Nol3tm1Rvh involves: C57BL/6 MGI:3711651


Genotype
MGI:3711651
hm1
Allelic
Composition
Nol3tm1Rvh/Nol3tm1Rvh
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nol3tm1Rvh mutation (0 available); any Nol3 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• mice show no significant difference in heart weight, body weight, heart/body weight ratio, or cardiomyocyte cross-sectional area at 12 weeks; no myofibrillar disarray, necrosis, or ventricular fibrosis is observed
• other tissues with abundant Nol3 expression appear normal
• under normal living conditions, mice do not display hypertrophy or heart failure up to 9 months of age
• at 4 weeks after thoracic aortic banding (TAB), mutants show accelerated left ventricle dilation compared to modestly dilated left ventricles in wild-type mice
• marked intermuscular cardiac fibrosis is seen in banded mutant hearts compared to banded wild-type
• fractional shortening measured 4 weeks after TAB is significantly reduced compared to controls after TAB
• 2 weeks after TAB, cardiomyocyte apoptosis frequency is significantly higher in mutant hearts than in banded wild-type hearts
• after conclusion of reperfusion after ischemia/reperfusion of hearts, mutant hearts have an enlarged area of infarction compared to wild-type hearts; mean size is increased 52.2% relative to wild-type

muscle
• fractional shortening measured 4 weeks after TAB is significantly reduced compared to controls after TAB
• 2 weeks after TAB, cardiomyocyte apoptosis frequency is significantly higher in mutant hearts than in banded wild-type hearts

respiratory system
• lung weight to body weight ratio is significantly higher after TAB relative to unbanded controls and knockouts

homeostasis/metabolism
• after conclusion of reperfusion after ischemia/reperfusion of hearts, mutant hearts have an enlarged area of infarction compared to wild-type hearts; mean size is increased 52.2% relative to wild-type

cellular
• 2 weeks after TAB, cardiomyocyte apoptosis frequency is significantly higher in mutant hearts than in banded wild-type hearts





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory