Phenotypes associated with this allele

• Allele Symbol: Nol3^tm1Rvh
• Allele Name: targeted mutation 1, Rudiger von Harsdorf
• Allele ID: MGI:3711185
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nol3^tm1Rvh/Nol3^tm1Rvh	involves: C57BL/6	MGI:3711651

Genotype
MGI:3711651

hm1

• Allelic Composition: Nol3^tm1Rvh/Nol3^tm1Rvh
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:121501 )

N • mice show no significant difference in heart weight, body weight, heart/body weight ratio, or cardiomyocyte cross-sectional area at 12 weeks; no myofibrillar disarray, necrosis, or ventricular fibrosis is observed

N • other tissues with abundant Nol3 expression appear normal

N • under normal living conditions, mice do not display hypertrophy or heart failure up to 9 months of age

dilated heart left ventricle ( J:121501 )

• at 4 weeks after thoracic aortic banding (TAB), mutants show accelerated left ventricle dilation compared to modestly dilated left ventricles in wild-type mice

cardiac fibrosis ( J:121501 )

• marked intermuscular cardiac fibrosis is seen in banded mutant hearts compared to banded wild-type

decreased ventricle muscle contractility ( J:121501 )

• fractional shortening measured 4 weeks after TAB is significantly reduced compared to controls after TAB

increased cardiomyocyte apoptosis ( J:121501 )

• 2 weeks after TAB, cardiomyocyte apoptosis frequency is significantly higher in mutant hearts than in banded wild-type hearts

increased myocardial infarct size ( J:121501 )

• after conclusion of reperfusion after ischemia/reperfusion of hearts, mutant hearts have an enlarged area of infarction compared to wild-type hearts; mean size is increased 52.2% relative to wild-type

muscle

decreased ventricle muscle contractility ( J:121501 )

• fractional shortening measured 4 weeks after TAB is significantly reduced compared to controls after TAB

increased cardiomyocyte apoptosis ( J:121501 )

• 2 weeks after TAB, cardiomyocyte apoptosis frequency is significantly higher in mutant hearts than in banded wild-type hearts

respiratory system

abnormal lung weight ( J:121501 )

• lung weight to body weight ratio is significantly higher after TAB relative to unbanded controls and knockouts

homeostasis/metabolism

increased myocardial infarct size ( J:121501 )

• after conclusion of reperfusion after ischemia/reperfusion of hearts, mutant hearts have an enlarged area of infarction compared to wild-type hearts; mean size is increased 52.2% relative to wild-type

cellular

increased cardiomyocyte apoptosis ( J:121501 )

• 2 weeks after TAB, cardiomyocyte apoptosis frequency is significantly higher in mutant hearts than in banded wild-type hearts