Phenotypes associated with this allele

• Allele Symbol: Foxp1^tm1Rao
• Allele Name: targeted mutation 1, Anjana Rao
• Allele ID: MGI:3711150
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxp1^tm1Rao/Foxp1^tm1Rao	B6.129-Foxp1^tm1Rao	MGI:3711661

Genotype
MGI:3711661

hm1

• Allelic Composition: Foxp1^tm1Rao/Foxp1^tm1Rao
• Genetic Background: B6.129-Foxp1^tm1Rao

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:112644 )

• embryos die at midgestation (E14.5)

hematopoietic system

abnormal B cell differentiation ( J:112644 )

• in bone marrow of recipients, numbers of Foxp1-null pro-B, pre-B and B220^hi B cells are lower than Foxp1 heterozygous B cells

arrested B cell differentiation ( J:112644 )

• transition from pro-B to pre-B cells is blocked in Foxp1-null cells in recipient bone marrow; defective immunoglobulin mu-chain production is observed

decreased mature B cell number ( J:112644 )

• when fetal liver cells are introduced into irradiated Rag2-deficient recipients, lower numbers of mature B cells are observed in the spleen and lymph nodes; Foxp1-null B cell numbers remain low in the periphery 15 weeks after transfer

abnormal B cell physiology ( J:112644 )

• V(D)J and DJ rearrangement is impaired in Foxp1-deficient pro-B cells in recipient mice

immune system

abnormal B cell differentiation ( J:112644 )

• in bone marrow of recipients, numbers of Foxp1-null pro-B, pre-B and B220^hi B cells are lower than Foxp1 heterozygous B cells

arrested B cell differentiation ( J:112644 )

• transition from pro-B to pre-B cells is blocked in Foxp1-null cells in recipient bone marrow; defective immunoglobulin mu-chain production is observed

decreased mature B cell number ( J:112644 )

• when fetal liver cells are introduced into irradiated Rag2-deficient recipients, lower numbers of mature B cells are observed in the spleen and lymph nodes; Foxp1-null B cell numbers remain low in the periphery 15 weeks after transfer

abnormal B cell physiology ( J:112644 )

• V(D)J and DJ rearrangement is impaired in Foxp1-deficient pro-B cells in recipient mice