Phenotypes associated with this allele

• Allele Symbol: Sptbn4^tm1Mkom
• Allele Name: targeted mutation 1, Masayuki Komada
• Allele ID: MGI:3710201
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sptbn4^tm1Mkom/Sptbn4^tm1Mkom	involves: 129S4/SvJaeSor * C57BL/6J	MGI:3710605

Genotype
MGI:3710605

hm1

• Allelic Composition: Sptbn4^tm1Mkom/Sptbn4^tm1Mkom
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

tremors ( J:120916 )

• first observable at weaning but milder than in Spnb4^{Gt(ROSABetageo)62Sor} homozygotes

nervous system

abnormal axon morphology ( J:120916 )

• neurons in the cerebral cortex, hippocampus and cerebral cortex exhibit wavy ankyrin G staining patterns of their axonal initial segments (AIS)

• AIS membranes are destabilized

abnormal myelination ( J:120916 )

• plasma membranes at the Node of Ranvier in the optic nerve are wavy, swollen and lack the fuzzy electron-dense undercoating present in wild-type mice

reproductive system

reproductive system phenotype ( J:120916 )

N • mice are fertile unlike male Spnb4^{Gt(ROSABetageo)62Sor} homozygotes