All Phenotypes Tg(Npy-hrGFP)1Lowl MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Npy-hrGFP)1Lowl
transgene insertion 1, Bradford B Lowell
MGI:3709190

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rock1^tm1.1Itl/Rock1^tm1.1Itl Tg(Npy-hrGFP)1Lowl/0 Tg(Pomc1-cre)16Lowl/0	involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	MGI:5543677
tg2	Tg(Npy-hrGFP)1Lowl/0	B6.FVB-Tg(Npy-hrGFP)1Lowl	MGI:3709260

Allelic Composition	Rock1^tm1.1Itl/Rock1^tm1.1Itl Tg(Npy-hrGFP)1Lowl/0 Tg(Pomc1-cre)16Lowl/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rock1^tm1.1Itl mutation (0 available); any Rock1 mutation (57 available)
Tg(Npy-hrGFP)1Lowl mutation (1 available)
Tg(Pomc1-cre)16Lowl mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system electrophysiology ( J:204885 )

• leptin fails to depolarize POMC+ neurons and increase firing rate unlike in control neurons

Allelic Composition	Tg(Npy-hrGFP)1Lowl/0
Genetic Background	B6.FVB-Tg(Npy-hrGFP)1Lowl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Npy-hrGFP)1Lowl mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:120993 )

• hemizygotes are viable and fertile

• when exposed to UV light, brain tissues show GFP fluorescence in patterns consistent with the endogenous mouse Npy gene

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