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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(tetO-APPSwInd)102Dbo
transgene insertion 102, David R Borchelt
MGI:3708167
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)102Dbo/0
involves: C3H/HeJ * C57BL/6 * CBA MGI:3709182
tg2
Tg(tetO-APPSwInd)102Dbo/0 involves: C3H/HeJ * C57BL/6J MGI:3709179


Genotype
MGI:3709182
cx1
Allelic
Composition
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)102Dbo/0
Genetic
Background
involves: C3H/HeJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-tTA)1Mmay mutation (6 available)
Tg(tetO-APPSwInd)102Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice produce transgenic APP protein at 10- to 30-fold over endogenous App levels (J:109829)
• suppression of transgene expression in these mice is most sensitive to doxycycline of the four lines tested (J:109829)
• mice produce transgenic APP protein at 10- to 30-fold over endogenous App levels (J:109829)
• suppression of transgene expression in these mice is most sensitive to doxycycline of the four lines tested (J:109829)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:109829




Genotype
MGI:3709179
tg2
Allelic
Composition
Tg(tetO-APPSwInd)102Dbo/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed
• no analysis of single transgenic mice provided (J:109829)
• no analysis of single transgenic mice provided (J:109829)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:109829





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory