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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rictortm1.2Mgn
targeted mutation 1.2, Mark A Magnuson
MGI:3703322
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rictortm1.2Mgn/Rictortm1.2Mgn involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL MGI:3706131
ht2
 		Rictortm1.2Mgn/Rictortm1.3Mgn involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL MGI:3706133
cn3
 		Rictortm1.1Mgn/Rictortm1.2Mgn
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N * SJL MGI:3706134


Genotype
MGI:3706131
hm1
Allelic
Composition		 Rictortm1.2Mgn/Rictortm1.2Mgn
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rictortm1.2Mgn mutation (0 available); any Rictor mutation (140 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:119564 )
• expected Mendelian distribution ratios by E9.5 and indistinguishable from either wild-type or heterozygous littermates
• showed growth arrest beginning between E9.5 and E10.5
• live embryos were not observed at E11.5

embryo
decreased embryo size ( J:119564 )
• at E10.5
• histologically normal and no major structural defects in any organ systems were found
abnormal placenta labyrinth morphology ( J:119564 )
• labyrinth layer remains cell dense in most E10.5 mutant placentas
abnormal placental labyrinth vasculature morphology ( J:119564 )
• exhibit fewer maternal-fetal interfaces in most E10.5 mutant placentas

cellular
decreased cell proliferation ( J:119564 )
• growth rate of mouse embryonic fibroblast from E9.5 embryos was slower than that of wild-type counterparts

growth/size/body
decreased embryo size ( J:119564 )
• at E10.5
• histologically normal and no major structural defects in any organ systems were found

cardiovascular system
abnormal placental labyrinth vasculature morphology ( J:119564 )
• exhibit fewer maternal-fetal interfaces in most E10.5 mutant placentas




Genotype
MGI:3706133
ht2
Allelic
Composition		 Rictortm1.2Mgn/Rictortm1.3Mgn
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rictortm1.2Mgn mutation (0 available); any Rictor mutation (140 available)
Rictortm1.3Mgn mutation (1 available); any Rictor mutation (140 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:119564 )
• expected Mendelian distribution ratios by E9.5 and indistinguishable from either wild-type or heterozygous littermates
• showed growth arrest beginning between E9.5 and E10.5
• live embryos were not observed at E11.5

embryo
abnormal placenta labyrinth morphology ( J:119564 )
• labyrinth layer remains cell dense in most E10.5 mutant placentas
abnormal placental labyrinth vasculature morphology ( J:119564 )
• exhibit fewer maternal-fetal interfaces in most E10.5 mutant placentas

growth/size/body
decreased embryo size ( J:119564 )
• at E10.5

cardiovascular system
abnormal placental labyrinth vasculature morphology ( J:119564 )
• exhibit fewer maternal-fetal interfaces in most E10.5 mutant placentas




Genotype
MGI:3706134
cn3
Allelic
Composition		 Rictortm1.1Mgn/Rictortm1.2Mgn
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Rictortm1.1Mgn mutation (1 available); any Rictor mutation (140 available)
Rictortm1.2Mgn mutation (0 available); any Rictor mutation (140 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:119564 )
• significantly lower than expected ratio of live embryos were obtained at E13.5 and E17.5, presumed to indicate embryonic lethality




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory