All Phenotypes Hoxa1<tm4(Hoxb1)Mrc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hoxa1^{tm4(Hoxb1)Mrc}
targeted mutation 4, Mario R Capecchi
MGI:3702592

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hoxa1^tm3.1Mrc/Hoxa1^{tm4(Hoxb1)Mrc}	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3703013
cx2	Hoxa1^tm3.1Mrc/Hoxa1^{tm4(Hoxb1)Mrc} Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc}	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6	MGI:3703012
cx3	Hoxa1^{tm4(Hoxb1)Mrc}/Hoxa1^{tm4(Hoxb1)Mrc} Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc}	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6	MGI:3703016
cx4	Hoxa1^{tm4(Hoxb1)Mrc}/Hoxa1^{tm4(Hoxb1)Mrc} Hoxb1^{tm8(Hoxa1)Mrc}/Hoxb1^{tm8(Hoxa1)Mrc}	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6	MGI:3703026

Allelic Composition	Hoxa1^tm3.1Mrc/Hoxa1^{tm4(Hoxb1)Mrc}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal reflex ( J:119279 )

• in response to an air puff, mice display defects ranging from complete inability to operate eyelids to mild defects where only a narrow slit remains open; 72% of animals are severely affected

• all animals were unable to completely close eyelids (eyeblink reflex) on at least one side

• 44% of mutants exhibit unilateral constraint of most anterior whisking range in response to air puff stimulus

• 7% exhibited one-sided weakness of pinna retraction in response to stimulus

facial paralysis ( J:119279 )

• mice show completely penetrant partial facial paralysis

nervous system

abnormal facial nerve morphology ( J:119279 )

• in mice with a severe eyeblink defect, zygomatic branch of facial nerve is exceedingly thin or absent; sometimes the nerve takes an aberrant trajectory

Allelic Composition	Hoxa1^tm3.1Mrc/Hoxa1^{tm4(Hoxb1)Mrc} Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa1^tm3.1Mrc mutation (0 available); any Hoxa1 mutation (14 available)
Hoxa1^{tm4(Hoxb1)Mrc} mutation (0 available); any Hoxa1 mutation (14 available)
Hoxb1^tm5Mrc mutation (0 available); any Hoxb1 mutation (24 available)
Hoxb1^{tm8(Hoxa1)Mrc} mutation (0 available); any Hoxb1 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal blinking ( J:119279 )

• facial paralysis is predominantly manifested in impaired eyeblink reflex

facial paralysis ( J:119279 )

• majority of mice show various levels of facial paralysis

Allelic Composition	Hoxa1^{tm4(Hoxb1)Mrc}/Hoxa1^{tm4(Hoxb1)Mrc} Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa1^{tm4(Hoxb1)Mrc} mutation (0 available); any Hoxa1 mutation (14 available)
Hoxb1^tm5Mrc mutation (0 available); any Hoxb1 mutation (24 available)
Hoxb1^{tm8(Hoxa1)Mrc} mutation (0 available); any Hoxb1 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal reflex ( J:119279 )

• eyeblink reflex is impaired in 58% of mutants; only 11% are considered to be severely affected

nervous system

abnormal facial nerve morphology ( J:119279 )

• zygomatic and temporal branches of facial nerve have normal caliber, but occasionally show atypical arborization pattern

Allelic Composition	Hoxa1^{tm4(Hoxb1)Mrc}/Hoxa1^{tm4(Hoxb1)Mrc} Hoxb1^{tm8(Hoxa1)Mrc}/Hoxb1^{tm8(Hoxa1)Mrc}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa1^{tm4(Hoxb1)Mrc} mutation (0 available); any Hoxa1 mutation (14 available)
Hoxb1^{tm8(Hoxa1)Mrc} mutation (0 available); any Hoxb1 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:119279 )

• mice do not show facial paralysis or behavioral abnormalities

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