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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rag2tm1Libo
targeted mutation 1, Lisa Borghesi
MGI:3700748
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rag2tm1Libo/Rag2tm1Libo involves: 129S6/SvEvTac * C57BL/6 * FVB/N MGI:3712280


Genotype
MGI:3712280
hm1
Allelic
Composition
Rag2tm1Libo/Rag2tm1Libo
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Libo mutation (0 available); any Rag2 mutation (82 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• IgM+ cells are reduced (15% compared to 29% in wild-type)
• B220+ cells are decreased by 2.5-fold, pre-B cells by 3-fold and IgM+ B cells by 3-fold compared to wild-type
• however, pro-B cell numbers are equivalent to wild-type
• the percentage of B220+ cells in the spleen is decreased
• cell number is decreased (15.6% compared to 37.5% in wild-type)
• splenocytes numbers are decreased
• V(D)J recombinase activity is diminished

immune system
• the percentage of B220+ cells in the spleen is decreased
• cell number is decreased (15.6% compared to 37.5% in wild-type)
• splenocytes numbers are decreased
• V(D)J recombinase activity is diminished





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory