About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rag2tm1Libo
targeted mutation 1, Lisa Borghesi
MGI:3700748
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rag2tm1Libo/Rag2tm1Libo involves: 129S6/SvEvTac * C57BL/6 * FVB/N MGI:3712280


Genotype
MGI:3712280
hm1
Allelic
Composition
Rag2tm1Libo/Rag2tm1Libo
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Libo mutation (0 available); any Rag2 mutation (117 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• IgM+ cells are reduced (15% compared to 29% in wild-type)
• B220+ cells are decreased by 2.5-fold, pre-B cells by 3-fold and IgM+ B cells by 3-fold compared to wild-type
• however, pro-B cell numbers are equivalent to wild-type
• the percentage of B220+ cells in the spleen is decreased
• cell number is decreased (15.6% compared to 37.5% in wild-type)
• splenocytes numbers are decreased
• V(D)J recombinase activity is diminished

immune system
• the percentage of B220+ cells in the spleen is decreased
• cell number is decreased (15.6% compared to 37.5% in wild-type)
• splenocytes numbers are decreased
• V(D)J recombinase activity is diminished





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory