Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp4ctm1Tht mutation
(0 available);
any
Ppp4c mutation
(40 available)
Tg(Lck-cre)548Jxm mutation
(2 available)
Tg(TcraTcrb)425Cbn mutation
(3 available)
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hematopoietic system
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• only marginal increase in numbers of CD4 positive thymocytes is observed compared to TCR-transgenic mice
• CD4 SP/DP ratio is 0.29 compared to 0.46 in controls, indicating reduced positive selection
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• a significant decrease in unfractionated, double-positive thymocyte numbers compared to single transgenic littermates abnormal CD4 T cell morphology
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• significant decrease in SP cell numbers
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immune system
|
• only marginal increase in numbers of CD4 positive thymocytes is observed compared to TCR-transgenic mice
• CD4 SP/DP ratio is 0.29 compared to 0.46 in controls, indicating reduced positive selection
|
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• a significant decrease in unfractionated, double-positive thymocyte numbers compared to single transgenic littermates abnormal CD4 T cell morphology
|
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• significant decrease in SP cell numbers
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp4ctm1Tht mutation
(0 available);
any
Ppp4c mutation
(40 available)
Tg(Lck-cre)548Jxm mutation
(2 available)
|
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immune system
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• developmental block specifically occurs at the double negative (DN) stage
• decreased percentage of TCR betahiCD3hi mature thymocytes as well as decreased cell numbers are observed
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• percentage of cells undergoing positive selection is decreased by ~60% compared to controls
• significant decrease in mature SP cell numbers
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• numbers of double negative (DN) cells are comparable to controls; however higher percentage of DN cells result
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• a significant decrease in unfractionated double-positive thymocyte numbers compared to Tg-negative littermates; 70% decrease is observed accompanying the developmental block
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• significant decrease in numbers
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• significant decrease in numbers
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• numbers of CD3+, Cd4+, and CD8+ T cells are decreased by ~50-60% in spleen and lymph nodes
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• antigen-specific T cell activation is decreased, with decreased proliferation in response to antigen observed
|
hematopoietic system
|
• developmental block specifically occurs at the double negative (DN) stage
• decreased percentage of TCR betahiCD3hi mature thymocytes as well as decreased cell numbers are observed
|
|
• percentage of cells undergoing positive selection is decreased by ~60% compared to controls
• significant decrease in mature SP cell numbers
|
|
• numbers of double negative (DN) cells are comparable to controls; however higher percentage of DN cells result
|
|
• a significant decrease in unfractionated double-positive thymocyte numbers compared to Tg-negative littermates; 70% decrease is observed accompanying the developmental block
|
|
• significant decrease in numbers
|
|
• significant decrease in numbers
|
|
• numbers of CD3+, Cd4+, and CD8+ T cells are decreased by ~50-60% in spleen and lymph nodes
|
|
• antigen-specific T cell activation is decreased, with decreased proliferation in response to antigen observed
|