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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Abcc4tm1Kruh
targeted mutation 1, Gary D Kruh
MGI:3697373
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Abcc4tm1Kruh/Abcc4tm1Kruh B6.129-Abcc4tm1Kruh MGI:3698034


Genotype
MGI:3698034
hm1
Allelic
Composition
Abcc4tm1Kruh/Abcc4tm1Kruh
Genetic
Background
B6.129-Abcc4tm1Kruh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc4tm1Kruh mutation (0 available); any Abcc4 mutation (121 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• LD50 is half of the LD50 for wild-type mice
• mutants show increased sensitivity to PMEA (a nucleotide analog); minimal toxic dose (0.5 mg/kg) is 5-fold lower than that of wild-type (2.5 mg/kg) and at dose of 2 mg/kg all mutants die, whereas wild-type all survive

growth/size/body
• after PMEA treatment (2 mg/kg), mutants show weight loss as early as 24 hours after treatment, and by day 5 have lost >20% body weight whereas wild-type mice have lost <5% body weight by this time

homeostasis/metabolism

digestive/alimentary system
• epithelium of forestomach is damaged by acute mucositis, leaving horny layer and denuded subepithelial tissue after PMEA treatment
• villi are decreased in size in mice after PMEA treatment
• basal portions of glands are dilated
• denuded subepithelial tissue shows edema and inflammatory cell infiltrate
• mutants display severe atrophic toxic colitis after PMEA treatment, with loss of glands, decreased submucosal thickness, and inflammatory infiltrates; microcysts are also present
• there are prominent inflammatory infiltrates in submucosa after PMEA treatment

hematopoietic system
• almost complete lymphoid depopulation in cortical region of thymus is observed in mutant thymus after PMEA treatment
• erythroid and myeloid populations in red pulp are decreased, and replaced with stromal cells after PMEA treatment
• after PMEA treatment, spleens are smaller in mutants
• lymphoid follicles are reduced in number and size

immune system
• denuded subepithelial tissue shows edema and inflammatory cell infiltrate
• mutants display severe atrophic toxic colitis after PMEA treatment, with loss of glands, decreased submucosal thickness, and inflammatory infiltrates; microcysts are also present
• there are prominent inflammatory infiltrates in submucosa after PMEA treatment
• almost complete lymphoid depopulation in cortical region of thymus is observed in mutant thymus after PMEA treatment
• erythroid and myeloid populations in red pulp are decreased, and replaced with stromal cells after PMEA treatment
• after PMEA treatment, spleens are smaller in mutants
• lymphoid follicles are reduced in number and size

cardiovascular system
• mutants have 1.8-fold higher brain/plasma ratios of PMEA compared to wild-type

nervous system
• mutants have 1.8-fold higher brain/plasma ratios of PMEA compared to wild-type

endocrine/exocrine glands
• almost complete lymphoid depopulation in cortical region of thymus is observed in mutant thymus after PMEA treatment





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/19/2021
MGI 6.16
The Jackson Laboratory