Analysis Tools
normal phenotype
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• homozygotes are viable, fertile and display no gross physical or behavioral abnormalities
• transgene gives a read-out of beta-catenin activity by expression of beta-galactosidase; expression is initially detectable at E6 in posterior side of proximal epiblast and is observed in the posterior primitive streak and node at gastrulation, progressing to the paraxial mesoderm and notochord
• expression in developing and adult tissues mimics the pattern of Wnt signaling
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