Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CD2-Ceacam1*4L)1Rsb mutation
(0 available)
Tg(TcraTcrb)425Cbn mutation
(3 available)
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immune system
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• CD4+ spleen cells exhibit decreased proliferation and IL-2 production in response to OVA (ovalbumin) and OVA peptide compared to Tg(TcraTcrb)425Cbn mice
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hematopoietic system
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• CD4+ spleen cells exhibit decreased proliferation and IL-2 production in response to OVA (ovalbumin) and OVA peptide compared to Tg(TcraTcrb)425Cbn mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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hematopoietic system
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• a decrease in CD3+ T cell population in total splenocytes is observed
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• transgene expression increases the amount of Ceacam1 on the surface of transgenic cells in the thymus and in peripheral lymph nodes, but not in intestinal epithelial lymphocytes (iIEL)
• cells are less responsive than wild-type cells in a mixed lymphocyte response (MLR) assay
• cells exhibit decreased contact sensitivity response to oxazolone
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• cells show lower proliferation compared to wild-type
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immune system
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• a decrease in CD3+ T cell population in total splenocytes is observed
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• transgene expression increases the amount of Ceacam1 on the surface of transgenic cells in the thymus and in peripheral lymph nodes, but not in intestinal epithelial lymphocytes (iIEL)
• cells are less responsive than wild-type cells in a mixed lymphocyte response (MLR) assay
• cells exhibit decreased contact sensitivity response to oxazolone
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• cells show lower proliferation compared to wild-type
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• transgenic T cells produce less IL-2 than wild-type with anti-CD3 and -CD28 stimulation
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cellular
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• cells show lower proliferation compared to wild-type
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