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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Akap8Gt(XG068)Byg
gene trap XG068, BayGenomics
MGI:3694775
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Akap8Gt(XG068)Byg/Akap8Gt(XG068)Byg involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6 MGI:3696035
cx2
 		Akap8Gt(XG068)Byg/Akap8Gt(XG068)Byg
Fignfi/Fignfi 		involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6 MGI:3696026
cx3
 		Akap8Gt(XG068)Byg/Akap8+
Fignfi/Fignfi 		involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6 MGI:3696027
cx4
 		Akap8Gt(XG068)Byg/Akap8Gt(XG068)Byg
Fignfi/Fign+ 		involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6 MGI:3696029


Genotype
MGI:3696035
hm1
Allelic
Composition		 Akap8Gt(XG068)Byg/Akap8Gt(XG068)Byg
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap8Gt(XG068)Byg mutation (0 available); any Akap8 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:116474 )
• mice show no overt abnormalities




Genotype
MGI:3696026
cx2
Allelic
Composition		 Akap8Gt(XG068)Byg/Akap8Gt(XG068)Byg
Fignfi/Fignfi
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap8Gt(XG068)Byg mutation (0 available); any Akap8 mutation (44 available)
Fignfi mutation (2 available); any Fign mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Cleft palate in Akap8Gt(XG068)Byg/Akap8Gt(XG068)Byg Fignfi/Fignfi mice

mortality/aging
neonatal lethality, incomplete penetrance ( J:116474 )
• double mutants survive through birth, but ~50% die within a few hours of birth
postnatal lethality, complete penetrance ( J:116474 )
• surviving mutants are generally smaller than littermates, do not nurse well, and gradually die prior to weaning, with very few surviving to 3 weeks (3/258)

craniofacial
cleft secondary palate ( J:116474 )
• 50% of newborns show complete cleft of the secondary palate

respiratory system
respiratory distress ( J:116474 )
• some newborns display gasping

digestive/alimentary system
cleft secondary palate ( J:116474 )
• 50% of newborns show complete cleft of the secondary palate

homeostasis/metabolism
cyanosis ( J:116474 )
• some newborns retain blue skin color (exhibit cyanosis) prior to death

growth/size/body
cleft secondary palate ( J:116474 )
• 50% of newborns show complete cleft of the secondary palate




Genotype
MGI:3696027
cx3
Allelic
Composition		 Akap8Gt(XG068)Byg/Akap8+
Fignfi/Fignfi
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap8Gt(XG068)Byg mutation (0 available); any Akap8 mutation (44 available)
Fignfi mutation (2 available); any Fign mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft secondary palate ( J:116474 )
• ~20% display cleft palate

digestive/alimentary system
cleft secondary palate ( J:116474 )
• ~20% display cleft palate

growth/size/body
cleft secondary palate ( J:116474 )
• ~20% display cleft palate




Genotype
MGI:3696029
cx4
Allelic
Composition		 Akap8Gt(XG068)Byg/Akap8Gt(XG068)Byg
Fignfi/Fign+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap8Gt(XG068)Byg mutation (0 available); any Akap8 mutation (44 available)
Fignfi mutation (2 available); any Fign mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft secondary palate ( J:116474 )
• 2% display cleft palate

digestive/alimentary system
cleft secondary palate ( J:116474 )
• 2% display cleft palate

growth/size/body
cleft secondary palate ( J:116474 )
• 2% display cleft palate




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory