Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plagl1tm1Jour mutation
(0 available);
any
Plagl1 mutation
(32 available)
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growth/size/body
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• body weight is reduced by ~23% at birth (P0) compared to wild-type or heterozygotes with maternally inherited allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plagl1tm1Jour mutation
(0 available);
any
Plagl1 mutation
(32 available)
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mortality/aging
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• 50% of mice with paternally inherited allele die within 24 hours after birth
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• litters obtained from heterozygous males mated with wild-type females have about 20% of the expected number of heterozygotes compared to heterozygous female/wild-type male matings when genotyped at 3 weeks
• 20% of pups with paternally inherited allele surviving past first day after birth die before day 3; no animals with obvious malformations survive past day 3
• Background Sensitivity: lethality is greater than on 129/CBA background
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growth/size/body
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• at birth, weight is reduced 23% in heterozygotes inheriting mutated allele paternally
• mice with paternally inherited allele display reduced lung and heart weight relative to body weight
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• at E16.5, weight reduction is 11% in heterozygotes inheriting mutated allele paternally
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limbs/digits/tail
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• abnormal ossification of last forelimb phalanx with paternally inherited allele
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• the most caudal vertebrae show abnormal ossification with paternally inherited allele
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• 1/3 of mice with paternally inherited allele have curly tails
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respiratory system
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• lungs are not inflated or imperfectly inflated in mice that die after birth
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• with paternally inherited allele, heterozygotes display dyspnea at birth
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cardiovascular system
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• mice with paternally inherited allele display reduced heart weight relative to body weight
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skeleton
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• abnormal ossification of last forelimb phalanx with paternally inherited allele
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• the most caudal vertebrae show abnormal ossification with paternally inherited allele
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• mice with paternally inherited allele show abnormal ossification of the most caudal vertebrae, ankle bones and last forelimb phalanx
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cellular
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• mice receiving paternal copy of null allele are phenotypically abnormal and display significant postnatal lethality
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integument
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• 1/3 of mice with paternally inherited allele display wrinkled skin
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plagl1tm1Jour mutation
(0 available);
any
Plagl1 mutation
(32 available)
|
|
|
mortality/aging
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• Background Sensitivity: lethality with paternally inherited allele is observed on this background, but is less than on 129/C57BL/6 background
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cellular
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• mice receiving paternal copy of null allele are phenotypically abnormal and display postnatal lethality
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Analysis Tools
