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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cdc42tm1Yizh
targeted mutation 1, Yi Zheng
MGI:3693320
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Cdc42tm1Yizh/Cdc42tm1Yizh
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd MGI:3693870


Genotype
MGI:3693870
cn1
Allelic
Composition
Cdc42tm1Yizh/Cdc42tm1Yizh
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc42tm1Yizh mutation (1 available); any Cdc42 mutation (42 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• numbers of homozygotes starts to decline after E13.5

nervous system
• mutant embryos display a much thicker neuroepithelium (NE) wall, and a lack of telencephalic vesicle enlargement in the developing forebrain at E10.5
• roof plate has thinner NE wall and lacked invagination of dorsal telencephalon
• apical-basal polarity of NE of developing forebrain is disrupted
• at E12.5, telencephalon remains single chambered and clear distinction between cortical plate and ganglionic eminences is absent
• in E11.5 mutants, neural progenitors and postmitotic neurons are intermingled throughout NE but in wild-type brain, progenitors are mainly confined to ventricular surface of forebrain and postmitotic neurons are found along apical-basal NE axis
• roof plate lacks invagination of dorsal telencephalon at E12.5
• between E9.5-12.5, mutants do not exhibit enlargement of telencephalic vesicles in contrast to wild-type embryos

vision/eye
• in E9.5-12.5 mutants, eye development is delayed compared to wild-type

embryo
• mutant embryos display a much thicker neuroepithelium (NE) wall, and a lack of telencephalic vesicle enlargement in the developing forebrain at E10.5
• roof plate has thinner NE wall and lacked invagination of dorsal telencephalon
• apical-basal polarity of NE of developing forebrain is disrupted





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory