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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Or8a1tm28(cre)Mom
targeted mutation 28, Peter Mombaerts
MGI:3692997
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gnastm5.1Lsw/Gnastm5.1Lsw
Gt(ROSA)26Sortm1(CAG-Mapt/GFP)Uboe/Gt(ROSA)26Sor+
Or8a1tm28(cre)Mom/Or8a1tm27Mom 		involves: 129P2/OlaHsd * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J MGI:5788923
cn2
 		Nrp1tm2Ddg/Nrp1tm2Ddg
Or8a1tm28(cre)Mom/Or8a1tm28(cre)Mom
Tg(CAG-Bgeo/GFP)21Lbe/? 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:6117236
cn3
 		Gt(ROSA)26Sortm5Mom/?
Or8a1tm28(cre)Mom/? 		involves: 129P2/OlaHsd * C57BL/6 MGI:5788565


Genotype
MGI:5788923
cn1
Allelic
Composition		 Gnastm5.1Lsw/Gnastm5.1Lsw
Gt(ROSA)26Sortm1(CAG-Mapt/GFP)Uboe/Gt(ROSA)26Sor+
Or8a1tm28(cre)Mom/Or8a1tm27Mom
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnastm5.1Lsw mutation (1 available); any Gnas mutation (53 available)
Gt(ROSA)26Sortm1(CAG-Mapt/GFP)Uboe mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Or8a1tm27Mom mutation (1 available); any Or8a1 mutation (69 available)
Or8a1tm28(cre)Mom mutation (2 available); any Or8a1 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
taste/olfaction
taste/olfaction phenotype ( J:233447 )
N
• axons of OLFR151 expressing olfactory sensory neurons appear to co-converge and coalesce in glomerular formation correctly despite G-protein disruption during development




Genotype
MGI:6117236
cn2
Allelic
Composition		 Nrp1tm2Ddg/Nrp1tm2Ddg
Or8a1tm28(cre)Mom/Or8a1tm28(cre)Mom
Tg(CAG-Bgeo/GFP)21Lbe/?
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm2Ddg mutation (1 available); any Nrp1 mutation (81 available)
Or8a1tm28(cre)Mom mutation (2 available); any Or8a1 mutation (69 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory bulb development ( J:255954 )
• olfactory sensory neurons expressing the null allele of Nrp1 have an altered and variable pattern of glomeruli formation in the olfactory bulb, including ectopic glomeruli, but the labeled glomeruli do not show an anterior shift relative to Nrp1 wild type controls




Genotype
MGI:5788565
cn3
Allelic
Composition		 Gt(ROSA)26Sortm5Mom/?
Or8a1tm28(cre)Mom/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm5Mom mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Or8a1tm28(cre)Mom mutation (2 available); any Or8a1 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
taste/olfaction
taste/olfaction phenotype ( J:233447 )
N
• axons of OLFR151 expressing olfactory sensory neurons appear to co-converge and coalesce in glomerular formation correctly despite G-protein disruption
abnormal olfactory sensory neuron physiology ( J:233447 )
• the olfactory sensory neurons expressing the dominant negative GNAS exhibit reduced numbers of spontaneous spikes and a significantly higher instantaneous firing frequency in perforated patch-clamp recordings

nervous system
abnormal olfactory sensory neuron physiology ( J:233447 )
• the olfactory sensory neurons expressing the dominant negative GNAS exhibit reduced numbers of spontaneous spikes and a significantly higher instantaneous firing frequency in perforated patch-clamp recordings

respiratory system
abnormal olfactory sensory neuron physiology ( J:233447 )
• the olfactory sensory neurons expressing the dominant negative GNAS exhibit reduced numbers of spontaneous spikes and a significantly higher instantaneous firing frequency in perforated patch-clamp recordings




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory