Analysis Tools
craniofacial
| N |
• at E14.5, mice exhibit normal palatal development and palatal shelf cell survival relative controls
|
|
Allele Symbol Allele Name Allele ID |
Boctm1Aok targeted mutation 1, Ami Okada MGI:3692939 |
||||||||||||||||||||||||
| Summary |
5 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• at E14.5, mice exhibit normal palatal development and palatal shelf cell survival relative controls
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• at E11.5 neural tube patterning appears normal
|
|
• at E11.5 TAG+ commissural neuron projects are highly dispersed and invade the ventral spinal cord with ectopic projections extending over the motor columns
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit a craniofacial midline comparable to that of wild type mice, with normal palatal development at E14.5 and normal Shh activity in the palatal shelves at E12.5
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• at E14.5, mice exhibit microform holoprosencephaly
|
|
• at E14.5, mice show a higher cell packing index (CPI, a measure of cell density) within the palatal shelf mesenchymal component than double heterozygous controls
• at E14.5, mice also show a higher proliferation index per unit area (PIPUA) within palatal shelf mesenchyme than double heterozygous controls, but to a lesser extent than in Boctm1Aok homozygotes (which have the lowest CPI and highest PIPUA value amongst genotypes)
|
|
• at E14.5, TUNEL assays showed lower levels of apoptosis within anterior, medial and posterior sections of the palatal shelves than in double heterozygous controls
|
|
• at E14.5, mice exhibit cleft palate with incomplete penetrance
|
|
• at E14.5, mice show a higher cell packing index (CPI, a measure of cell density) within the palatal shelf mesenchymal component than double heterozygous controls
• at E14.5, mice also show a higher proliferation index per unit area (PIPUA) within palatal shelf mesenchyme than double heterozygous controls, but to a lesser extent than in Boctm1Aok homozygotes (which have the lowest CPI and highest PIPUA value amongst genotypes)
|
|
• at E14.5, TUNEL assays showed lower levels of apoptosis within anterior, medial and posterior sections of the palatal shelves than in double heterozygous controls
|
|
• at E14.5, mice exhibit cleft palate with incomplete penetrance
|
|
• at E14.5, mice show a higher cell packing index (CPI, a measure of cell density) within the palatal shelf mesenchymal component than double heterozygous controls
• at E14.5, mice also show a higher proliferation index per unit area (PIPUA) within palatal shelf mesenchyme than double heterozygous controls, but to a lesser extent than in Boctm1Aok homozygotes (which have the lowest CPI and highest PIPUA value amongst genotypes)
|
|
• at E14.5, TUNEL assays showed lower levels of apoptosis within anterior, medial and posterior sections of the palatal shelves than in double heterozygous controls
|
|
• at E14.5, mice exhibit cleft palate with incomplete penetrance
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• at E14.5, mice show a higher proliferation index per unit area (PIPUA) within palatal shelf mesenchyme than double heterozygous controls, but to a lesser extent than in Boctm1Aok homozygotes (which have the lowest cell packing index (CPI) value and highest PIPUA value amongst genotypes)
• however, the CPI value is not statistically different from that in double heterozygous controls
|
|
• at E12.5, expression levels of Shh and its target genes Ptch1 and Gli1 are reduced, indicating reduced Shh activity in the palatal shelves during palate development
• at E14.5, TUNEL assays showed lower levels of apoptosis within anterior, medial and posterior sections of the palatal shelves than in double heterozygous controls
• despite increased mesenchymal proliferation and reduced epithelial cell death, palatal shelf size is similar to that in double heterozygous controls
|
|
• at E14.5, mice exhibit a fully penetrant cleft palate
|
|
• at E14.5, mice show failure of palatal shelf (PS) elevation above the tongue
|
|
• at E14.5, a midline cleft is noted within the posterior third of the tongue in the pharyngeal region
|
|
• at E14.5, the vomeronasal organ is abnormally positioned
|
|
• at E14.5, mice show a higher proliferation index per unit area (PIPUA) within palatal shelf mesenchyme than double heterozygous controls, but to a lesser extent than in Boctm1Aok homozygotes (which have the lowest cell packing index (CPI) value and highest PIPUA value amongst genotypes)
• however, the CPI value is not statistically different from that in double heterozygous controls
|
|
• at E12.5, expression levels of Shh and its target genes Ptch1 and Gli1 are reduced, indicating reduced Shh activity in the palatal shelves during palate development
• at E14.5, TUNEL assays showed lower levels of apoptosis within anterior, medial and posterior sections of the palatal shelves than in double heterozygous controls
• despite increased mesenchymal proliferation and reduced epithelial cell death, palatal shelf size is similar to that in double heterozygous controls
|
|
• at E14.5, mice exhibit a fully penetrant cleft palate
|
|
• at E14.5, mice show failure of palatal shelf (PS) elevation above the tongue
|
|
• at E14.5, a midline cleft is noted within the posterior third of the tongue in the pharyngeal region
|
|
• at E14.5, mice show a higher proliferation index per unit area (PIPUA) within palatal shelf mesenchyme than double heterozygous controls, but to a lesser extent than in Boctm1Aok homozygotes (which have the lowest cell packing index (CPI) value and highest PIPUA value amongst genotypes)
• however, the CPI value is not statistically different from that in double heterozygous controls
|
|
• at E12.5, expression levels of Shh and its target genes Ptch1 and Gli1 are reduced, indicating reduced Shh activity in the palatal shelves during palate development
• at E14.5, TUNEL assays showed lower levels of apoptosis within anterior, medial and posterior sections of the palatal shelves than in double heterozygous controls
• despite increased mesenchymal proliferation and reduced epithelial cell death, palatal shelf size is similar to that in double heterozygous controls
|
|
• at E14.5, mice exhibit a fully penetrant cleft palate
|
|
• at E14.5, mice show failure of palatal shelf (PS) elevation above the tongue
|
|
• at E14.5, a midline cleft is noted within the posterior third of the tongue in the pharyngeal region
|
|
• at E14.5, the vomeronasal organ is abnormally positioned
|
|
• at E14.5, the vomeronasal organ is abnormally positioned
|
|
• at E14.5, the vomeronasal organ is abnormally positioned
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/16/2024 MGI 6.23 |
|
|
|
||