About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rettm13.1Jmi
targeted mutation 13.1, Jeffrey Milbrandt
MGI:3691588
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rettm13.1Jmi/Rettm13.1Jmi involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:3692550
cn2
 		Rettm13.1Jmi/Rettm13Jmi
Slc6a3tm1(cre)Xz/Slc6a3+ 		involves: 129S1/Sv * 129X1/SvJ MGI:3692551


Genotype
MGI:3692550
hm1
Allelic
Composition		 Rettm13.1Jmi/Rettm13.1Jmi
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rettm13.1Jmi mutation (1 available); any Ret mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:114682 )
N
• midbrain dopaminergic neurons develop normally
absent enteric neurons ( J:114682 )
• mice display intestinal aganglionosis

renal/urinary system
absent kidney ( J:114682 )
• renal agenesis occurs in homozygotes, identical to conventional Ret-null animals




Genotype
MGI:3692551
cn2
Allelic
Composition		 Rettm13.1Jmi/Rettm13Jmi
Slc6a3tm1(cre)Xz/Slc6a3+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rettm13.1Jmi mutation (1 available); any Ret mutation (53 available)
Rettm13Jmi mutation (1 available); any Ret mutation (53 available)
Slc6a3tm1(cre)Xz mutation (2 available); any Slc6a3 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased locomotor activity ( J:114682 )
• adults are modestly but significantly less active than heterozygous controls; total ambulations during a 1 hour observation session are lower in conditional null mice
• mice exhibit normal rearing behavior but travel less in the field periphery and make fewer entries into center compared to controls

nervous system
nervous system phenotype ( J:114682 )
N
• although Ret expression is lost, in adults the total cell counts and size of dopaminergic neurons, TH-positive fiber density in the striatum and nucleus accumbens, nigrostriatal and ventral tegmental area pathways, and levels of dopamine and its metabolites, are all similar to wild-type
• mice do not appear to have sensorimotor deficits with the modest decrease in locomotor activity




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory