Mouse Genome Informatics
hm1
    Gfaptm1Hgmn/Gfaptm1Hgmn
involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
growth/size
• weigh less than wild-type or heterozygotes

nervous system
• develop more Rosenthal fibers than heterozygotes


Mouse Genome Informatics
ht2
    Gfaptm1Hgmn/Gfap+
involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
growth/size

nervous system
• develop Rosenthal fibers, especially within the hippocampus, olfactory bulb, corpus callosum, and rostral extension, as well as in subpial, perivascular and periventricular regions
• exhibit fewer Rosenthal fibers than seen in heterozygous Gfaptm2Hgmn mutants

Mouse Models of Human Disease
OMIM IDRef(s)
Alexander Disease 203450 J:114689