Mouse Genome Informatics
hm1
     Gfaptm1Hgmn/Gfaptm1Hgmn
involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
growth/size
decreased body weight ( J:114689 )
• weigh less than wild-type or heterozygotes

nervous system
abnormal astrocyte morphology ( J:114689 )
• develop more Rosenthal fibers than heterozygotes


Mouse Genome Informatics
ht2
     Gfaptm1Hgmn/Gfap+
involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
growth/size

nervous system
abnormal astrocyte morphology ( J:114689 )
• develop Rosenthal fibers, especially within the hippocampus, olfactory bulb, corpus callosum, and rostral extension, as well as in subpial, perivascular and periventricular regions
• exhibit fewer Rosenthal fibers than seen in heterozygous Gfaptm2Hgmn mutants

Mouse Models of Human Disease
 OMIM IDRef(s)
Alexander Disease 203450 J:114689