Phenotypes associated with this allele

• Allele Symbol: Pth1r^tm1Abas
• Allele Name: targeted mutation 1, Abdul B Abou-Samra
• Allele ID: MGI:3687642
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pth1r^tm1Abas/Pth1r^tm1Abas	B6.Cg-Pth1r^tm1Abas	MGI:3688528

Genotype
MGI:3688528

hm1

• Allelic Composition: Pth1r^tm1Abas/Pth1r^tm1Abas
• Genetic Background: B6.Cg-Pth1r^tm1Abas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal blood homeostasis ( J:113660 )

• after subcutaneous injection of rPTH, male mutants show elevated cAMP levels at all times after injection vs wild-type, with the peak concentration occurring at 15-20 minutes

decreased circulating parathyroid hormone level ( J:113660 )

• level are lower in males (14.4 pg/ml) than wild-type male littermates (46 pg/ml)

increased circulating calcium level ( J:113660 )

• in response to minimal infusion dose of PTH which induces mild hypocalcemia in wild-type, male mutants show striking increases in serum calcium levels; peak calcium level after 3 day infusion is 12.5 mg/dl in wild-type vs 22.2 mg/dl in mutants

abnormal circulating phosphate level ( J:113660 )

• levels are lower in males (6.39 mg/dl) vs wild-type males (7.46 mg/dl)

skeleton

abnormal osteoblast physiology ( J:113660 )

• cultured osteoblasts from mutants show sustained increase in cAMP levels in response to parathyroid hormone

cellular

abnormal osteoblast physiology ( J:113660 )

• cultured osteoblasts from mutants show sustained increase in cAMP levels in response to parathyroid hormone