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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pth1rtm1Abas
targeted mutation 1, Abdul B Abou-Samra
MGI:3687642
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pth1rtm1Abas/Pth1rtm1Abas B6.Cg-Pth1rtm1Abas MGI:3688528


Genotype
MGI:3688528
hm1
Allelic
Composition
Pth1rtm1Abas/Pth1rtm1Abas
Genetic
Background
B6.Cg-Pth1rtm1Abas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1rtm1Abas mutation (0 available); any Pth1r mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• cultured osteoblasts from mutants show sustained increase in cAMP levels in response to parathyroid hormone

homeostasis/metabolism
• after subcutaneous injection of rPTH, male mutants show elevated cAMP levels at all times after injection vs wild-type, with the peak concentration occurring at 15-20 minutes
• level are lower in males (14.4 pg/ml) than wild-type male littermates (46 pg/ml)
• in response to minimal infusion dose of PTH which induces mild hypocalcemia in wild-type, male mutants show striking increases in serum calcium levels; peak calcium level after 3 day infusion is 12.5 mg/dl in wild-type vs 22.2 mg/dl in mutants
• levels are lower in males (6.39 mg/dl) vs wild-type males (7.46 mg/dl)

skeleton
• cultured osteoblasts from mutants show sustained increase in cAMP levels in response to parathyroid hormone





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory