Mouse Genome Informatics
hm1
    Nlgn3tm1Bros/Nlgn3tm1Bros
B6.Cg-Nlgn3tm1Bros
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
N
• mice exhibit normal sucrose preference and hippocampal memory function in a Morris water maze (J:151116)
• mice display decreased freezing in hippocampus-dependent contextual fear conditioning compared with wild-type mice (J:151116)
• mice display decreased freezing in hippocampus-independent cued fear conditioning compared with wild-type mice (J:151116)
• mice exhibit increased motor activity, total distance traveled, and mean velocity compared with wild-type mice (J:151116)
• in an elevated plus maze, mice exhibit an increase in total distance traveled compared with wild-type mice (J:151116)
• in a hole board test, mice exhibit increased exploration compared with wild-type mice (J:151116)
• mice exhibit no preference for new stranger mouse unlike wild-type mice (J:151116)
• mice exhibit reduced ultrasound vocalization compared with wild-type mice (J:151116)

nervous system
N
• mice exhibit normal prepulse inhibition and seizure propensity (J:151116)
• brain volume is decreased compared to in wild-type mice (J:151116)

taste/olfaction
• mice exhibit increased latency to finding buried food compared with wild-type mice (J:151116)

Mouse Models of Human Disease
OMIM IDRef(s)
Autism, Susceptibility to, X-Linked 1; AUTSX1 300425 J:151116


Mouse Genome Informatics
cx2
    Nlgn1tm1Bros/Nlgn1tm1Bros
Nlgn3tm1Bros/Nlgn3tm1Bros

Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• mice exhibit striking deficits in raising offspring (J:113647)

nervous system
• in double nulls, high amplitude population of GABAergic and glycinergic sPSCs is decreased by <50%; numbers of sPSCs with lower amplitudes is moderately changed (J:113647)

reproductive system
• mice show drastically reduced reproduction rates (J:113647)


Mouse Genome Informatics
cx3
    Nlgn2tm1Bros/Nlgn2tm1Bros
Nlgn3tm1Bros/Nlgn3tm1Bros

Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• mice exhibit striking deficits in raising offspring (J:113647)

nervous system
• in double nulls, high amplitude population of GABAergic and glycinergic sPSCs is decreased by <50%; numbers of sPSCs with lower amplitudes is moderately changed (J:113647)

reproductive system
• mice show drastically reduced reproduction rates (J:113647)


Mouse Genome Informatics
cx4
    Nlgn1tm1Bros/Nlgn1tm1Bros
Nlgn2tm1Bros/Nlgn2tm1Bros
Nlgn3tm1Bros/Nlgn3tm1Bros

Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mice die within 24 hours after birth (J:113647)

growth/size/body
• mice have slightly reduced body weight compared to single or double knockout littermates (J:113647)

nervous system
• ratio of glutamatergic vs GABAergic/glycinergic terminals is reduced in the PBC and inferior olive in mutants, but not in hypoglossal neurons (J:113647)
• there is a 30% reduction in number of postsynaptic clusters containing GABAAR alpha 1in the PBC (J:113647)
• spontaneous postsynaptic currents from Pre-Botzinger complex (PBC) neurons are reduced in frequency and duration compared to single knockout animals (J:113647)
• number of GABAergic and glycinergic sPSCs with lower and higher amplitudes are decreased by 85% and 95% respectively (J:113647)
• frequency of GABAergic and glycinergic miniature PSCs (mPSCs) in PBC neurons is reduced by 80% compared to single knockout controls cells (J:113647)
• frequency of spontaneous glutamatergic postsynaptic currents is decreased compared to single null PBC neurons (J:113647)
• amplitudes of GABAergic/glycinergic evoked postsynaptic currents (ePSCs) are strongly decreased compared to single knockout neurons, while amplitudes in double knockout neurons is not significantly changed (J:113647)

respiratory system
• mice show irregular and flat breathing movements (J:113647)