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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(HIST1H2BB/EGFP)1Pa
transgene insertion 1, Virginia E Papaioannou
MGI:3686857
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Krt14tm1(cre)Wbm/Krt14+
Pard3tm1Shoh/Pard3tm1Shoh
Tg(HIST1H2BB/EGFP)1Pa/0 		involves: 129 * C57BL/6J MGI:6272614
cx2
 		Bub1btm1.1Hsl/Bub1b+
Tg(HIST1H2BB/EGFP)1Pa/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5543392
tg3
 		Tg(HIST1H2BB/EGFP)1Pa/Tg(HIST1H2BB/EGFP)1Pa involves: 129S1/Sv * 129X1/SvJ * ICR MGI:3687146


Genotype
MGI:6272614
cn1
Allelic
Composition		 Krt14tm1(cre)Wbm/Krt14+
Pard3tm1Shoh/Pard3tm1Shoh
Tg(HIST1H2BB/EGFP)1Pa/0
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt14tm1(cre)Wbm mutation (0 available); any Krt14 mutation (36 available)
Pard3tm1Shoh mutation (0 available); any Pard3 mutation (96 available)
Tg(HIST1H2BB/EGFP)1Pa mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal melanocyte morphology ( J:240961 )
• in P58 tail whole mounts, melanocytes (MCs) show a more stubby dendritic morphology with dendritic shortening and a more spread cell body area relative to MCs in control mice




Genotype
MGI:5543392
cx2
Allelic
Composition		 Bub1btm1.1Hsl/Bub1b+
Tg(HIST1H2BB/EGFP)1Pa/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bub1btm1.1Hsl mutation (0 available); any Bub1b mutation (58 available)
Tg(HIST1H2BB/EGFP)1Pa mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell nucleus morphology ( J:201641 )
• micronuclei due to lagging chromosomes in mouse embryonic fibroblasts, regenerating hepatocytes and hepatocellular carcinoma
aneuploidy ( J:201641 )
• in mouse embryonic fibroblasts
abnormal mitosis ( J:201641 )
• premature sister chromatid separation in mouse embryonic fibroblasts
• shortened mitotic timing
abnormal mitotic spindle assembly checkpoint ( J:201641 )
• weakened with chromosome mis-segregation, congression failure and severe defects in kinetochore-microtubule attachment in mouse embryonic fibroblasts




Genotype
MGI:3687146
tg3
Allelic
Composition		 Tg(HIST1H2BB/EGFP)1Pa/Tg(HIST1H2BB/EGFP)1Pa
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(HIST1H2BB/EGFP)1Pa mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:109836 )
• homozygotes are viable and fertile; the reporter is developmentally neutral




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory