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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ncam1tm1Klc
targeted mutation 1, Kathryn L Crossin
MGI:3665409
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ncam1tm1Klc/Ncam1tm1Klc either: (involves: 129 * C57BL/6J) or (involves: 129 * CD-1) MGI:3687197
ht2
 		Ncam1tm1Klc/Ncam1+ either: (involves: 129 * C57BL/6J) or (involves: 129 * CD-1) MGI:3687198


Genotype
MGI:3687197
hm1
Allelic
Composition		 Ncam1tm1Klc/Ncam1tm1Klc
Genetic
Background		 either: (involves: 129 * C57BL/6J) or (involves: 129 * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncam1tm1Klc mutation (0 available); any Ncam1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal hippocampus CA3 region morphology ( J:46176 )
• mice have a bifurcation of the CA3 region not present in wild-type, but similar to that found in other Ncam1 knockouts
small olfactory bulb ( J:46176 )
• reduced in size
abnormal postnatal subventricular zone morphology ( J:46176 )
• there is an increase in the number of cells in the subventricular zone




Genotype
MGI:3687198
ht2
Allelic
Composition		 Ncam1tm1Klc/Ncam1+
Genetic
Background		 either: (involves: 129 * C57BL/6J) or (involves: 129 * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncam1tm1Klc mutation (0 available); any Ncam1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal hippocampus CA3 region morphology ( J:46176 )
• mice have a less pronounced bifurctation of the CA3 region than homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory