Mouse Genome Informatics
ht1
    Ryr2tm1Slh/Ryr2+
involves: 129S7/SvEvBrd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cardiovascular system
• atrial pacing using atrial burst results in increased ectopic beats and reentry compared to in similarly treated wild-type mice
• atria myocyte exhibit increased sarcoplasmic reticulum calcium ion leak compared with wild-type cells
• mice are more susceptible to pacing-induced atrial fibrillation compared with similarly treated wild-type mice
• however, the increased susceptibility to pacing-induced atrial fibrillation can be rescued by over-expression of Adcy3 inhibitory peptide

homeostasis/metabolism
• mice are more susceptible to pacing-induced atrial fibrillation compared with similarly treated wild-type mice
• however, the increased susceptibility to pacing-induced atrial fibrillation can be rescued by over-expression of Adcy3 inhibitory peptide


Mouse Genome Informatics
ht2
    Ryr2tm1Slh/Ryr2+
involves: 129S7/SvEvBrd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Ryr2tm1Slh/Ryr+ MRI heart images

cardiovascular system
• systolic function is modestly reduced as demonstrated by decreased peak of aortic velocity
• exhibit a lowered right ventricular end-diastolic volume and higher right ventricular end-diastolic pressure, indicating restrictive ventricular filling, however show no evidence of fibrofatty infiltration or arrhythmogenic right ventricular dysplasia
• develop ventricular tachycardia after caffeine and epinephrine injection or with programmed ventricular stimulation
• multiple premature ventricular beats are seen after isoproterenol treatment (a beta-adrenergic receptor agonist), however no sustained ventricular arrhythmias are seen
• isolated cardiomyocytes exhibit a higher incidence of spontaneous calcium oscillations in the absence and presence of isoproterenol

muscle
• systolic function is modestly reduced as demonstrated by decreased peak of aortic velocity
• exhibit a lowered right ventricular end-diastolic volume and higher right ventricular end-diastolic pressure, indicating restrictive ventricular filling, however show no evidence of fibrofatty infiltration or arrhythmogenic right ventricular dysplasia