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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ryr2tm1Slh
targeted mutation 1, Susan L Hamilton
MGI:3665257
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Ryr2tm1Slh/Ryr2+ involves: 129S7/SvEvBrd MGI:4359617
ht2
Ryr2tm1Slh/Ryr2+ involves: 129S7/SvEvBrd * C57BL/6 MGI:3689179


Genotype
MGI:4359617
ht1
Allelic
Composition
Ryr2tm1Slh/Ryr2+
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ryr2tm1Slh mutation (0 available); any Ryr2 mutation (157 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• atrial pacing using atrial burst results in increased ectopic beats and reentry compared to in similarly treated wild-type mice
• atria myocyte exhibit increased sarcoplasmic reticulum calcium ion leak compared with wild-type cells
• mice are more susceptible to pacing-induced atrial fibrillation compared with similarly treated wild-type mice
• however, the increased susceptibility to pacing-induced atrial fibrillation can be rescued by over-expression of Adcy3 inhibitory peptide

homeostasis/metabolism
• mice are more susceptible to pacing-induced atrial fibrillation compared with similarly treated wild-type mice
• however, the increased susceptibility to pacing-induced atrial fibrillation can be rescued by over-expression of Adcy3 inhibitory peptide




Genotype
MGI:3689179
ht2
Allelic
Composition
Ryr2tm1Slh/Ryr2+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ryr2tm1Slh mutation (0 available); any Ryr2 mutation (157 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Ryr2tm1Slh/Ryr+ MRI heart images

cardiovascular system
• systolic function is modestly reduced as demonstrated by decreased peak of aortic velocity
• exhibit a lowered right ventricular end-diastolic volume and higher right ventricular end-diastolic pressure, indicating restrictive ventricular filling, however show no evidence of fibrofatty infiltration or arrhythmogenic right ventricular dysplasia
• develop ventricular tachycardia after caffeine and epinephrine injection or with programmed ventricular stimulation
• multiple premature ventricular beats are seen after isoproterenol treatment (a beta-adrenergic receptor agonist), however no sustained ventricular arrhythmias are seen
• isolated cardiomyocytes exhibit a higher incidence of spontaneous calcium oscillations in the absence and presence of isoproterenol

muscle
• systolic function is modestly reduced as demonstrated by decreased peak of aortic velocity
• exhibit a lowered right ventricular end-diastolic volume and higher right ventricular end-diastolic pressure, indicating restrictive ventricular filling, however show no evidence of fibrofatty infiltration or arrhythmogenic right ventricular dysplasia





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory