Phenotypes associated with this allele
Allelic Composition |
Gata6tm1Eno/Gata6tm1Eno
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Genetic Background |
either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6tm1Eno mutation
(0 available);
any
Gata6 mutation
(32 available)
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mortality/aging
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• no homozygotes are observed after E7.5
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embryo
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• failure in visceral endoderm differentiation
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Allelic Composition |
Gata4tm1Eno/Gata4+ Gata6tm1Eno/Gata6+
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Genetic Background |
involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1Eno mutation
(0 available);
any
Gata4 mutation
(36 available)
Gata6tm1Eno mutation
(0 available);
any
Gata6 mutation
(32 available)
|
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mortality/aging
cardiovascular system
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• cranial and intersomitic vasculature is enlarged and disorganized at E10.5
• exhibit thin and dilated vessels
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• hypoplastic transcending aortic arch
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• hypoplastic aorta at E12.5
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• show a reduction in the arterial smooth muscle
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• at E12.5, mutants show less smooth muscle in the medial layer of the aorta
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• hearts at E13.5 contain only two myocardial cell layers within the compact zone instead of the normal five layers
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• myocardial thinning becomes apparent at E12.5
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• exhibit patterning defects of the outflow tract at E12
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• seen at E12, resulting from incomplete septation of the conotruncus into the aorta and pulmonary artery
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• exhibit a modest delay in the formation of the ventricular septum beginning at E11.5
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• show ventricular septal defects that persist until death
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• display widespread hemorrhages by E11.5
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• display reduced cardiomyocyte proliferation at E10.5
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• heartbeat at E11.75 is sluggish and irregular
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hematopoietic system
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• reduction in the number of mature erythrocytes in peripheral blood
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homeostasis/metabolism
liver/biliary system
muscle
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• show a reduction in the arterial smooth muscle
|
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• at E12.5, mutants show less smooth muscle in the medial layer of the aorta
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• hearts at E13.5 contain only two myocardial cell layers within the compact zone instead of the normal five layers
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• myocardial thinning becomes apparent at E12.5
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• display reduced cardiomyocyte proliferation at E10.5
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cellular
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• display reduced cardiomyocyte proliferation at E10.5
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