Phenotypes associated with this allele

• Allele Symbol: Hsh2d^tm1Viss
• Allele Name: targeted mutation 1, Virginia Smith Shapiro
• Allele ID: MGI:3662663
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hsh2d^tm1Viss/Hsh2d^tm1Viss	B6.129-Hsh2d^tm1Viss	MGI:3662922
hm2	Hsh2d^tm1Viss/Hsh2d^tm1Viss	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3662923

Genotype
MGI:3662922

hm1

• Allelic Composition: Hsh2d^tm1Viss/Hsh2d^tm1Viss
• Genetic Background: B6.129-Hsh2d^tm1Viss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:111408 )

N • mice show normal T and B cell development, normal antibody production after immunization with TNP-KLH and normal B cell survival and proliferation after stimulation with anti-IgM, anti-CD40, BLyS, LPS and CpG

increased T cell proliferation ( J:111408 )

• purified T cells from mutants show increased proliferation compared to wild-type

increased interleukin-2 secretion ( J:111408 )

• isolated T cells produce more IL-2 upon stimulation by CD3/CD28 than wild-type cells

hematopoietic system

increased T cell proliferation ( J:111408 )

• purified T cells from mutants show increased proliferation compared to wild-type

cellular

increased T cell proliferation ( J:111408 )

• purified T cells from mutants show increased proliferation compared to wild-type

Genotype
MGI:3662923

hm2

• Allelic Composition: Hsh2d^tm1Viss/Hsh2d^tm1Viss
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

hematopoietic system

increased spleen weight ( J:111408 )

• aged mutant mice show mild splenomegaly with some (4/15) having spleen weights 3-fold greater than normal with 2 having a 10-fold increase in spleen size

abnormal CD4-positive, alpha-beta T cell physiology ( J:111408 )

• more CD4+ T cells in mutant spleens show an activated phenotype

abnormal CD8-positive, alpha-beta T cell physiology ( J:111408 )

• more CD8+ T cells show an activated phenotype than do cells in wild-type spleens

immune system

increased spleen weight ( J:111408 )

• aged mutant mice show mild splenomegaly with some (4/15) having spleen weights 3-fold greater than normal with 2 having a 10-fold increase in spleen size

abnormal CD4-positive, alpha-beta T cell physiology ( J:111408 )

• more CD4+ T cells in mutant spleens show an activated phenotype

abnormal CD8-positive, alpha-beta T cell physiology ( J:111408 )

• more CD8+ T cells show an activated phenotype than do cells in wild-type spleens

growth/size/body

increased spleen weight ( J:111408 )

• aged mutant mice show mild splenomegaly with some (4/15) having spleen weights 3-fold greater than normal with 2 having a 10-fold increase in spleen size