All Phenotypes Msc<tm1Eno> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Msc^tm1Eno/Msc^tm1Eno	involves: 129	MGI:3655695
cx2	Msc^tm1Eno/Msc^tm1Eno Tcf21^tm2Eno/Tcf21^tm2Eno	involves: 129 * Black Swiss	MGI:3655699
cx3	Msc^tm1Eno/Msc⁺ Tcf21^tm2Eno/Tcf21^tm2Eno	involves: 129 * Black Swiss	MGI:3655867
cx4	Msc^tm1Eno/Msc^tm1Eno Tcf21^tm2Eno/Tcf21⁺	involves: 129 * Black Swiss	MGI:3655869

Allelic Composition	Msc^tm1Eno/Msc^tm1Eno
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msc^tm1Eno mutation (1 available); any Msc mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:111337 )

• homozygotes are obtained at the expected Mendelian ratios and show no obvious abnormalities

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:111337 )

• double homozygotes are born alive, but similar to single Tcf21^tm2Eno homozygotes, they die within minutes after birth

muscle

abnormal masticatory muscle morphology ( J:111337 )

• most double homozygotes show a complete absence of the major muscles of mastication, not observed in either single homozygote

absent masseter muscle ( J:111337 )

• most double homozygotes show a complete absence of the masseter muscle

abnormal pterygoid muscle morphology ( J:111337 )

• atrophic pterygoid myofibers are found to persist unilaterally in a subset of double homozygotes

absent pterygoid muscle ( J:111337 )

• most double homozygotes show a complete absence of the medial and lateral pterygoid muscles

absent temporalis muscle ( J:111337 )

• most double homozygotes show a complete absence of the temporalis muscle

abnormal myogenesis ( J:111337 )

• at E10.5, TUNEL labeling indicates that first branchial arch muscle precursor cells undergo apoptosis resulting in ablation of masticatory muscles

• notably, other first arch-derived muscles, e.g. the anterior digastric and mylohyoid, which do not function in mastication, are present and trunk muscles appear unaffected

diaphragmatic hernia ( J:111337 )

• double homozygotes exhibit diaphragmatic hernia with visceral organs being displaced into the chest

craniofacial

abnormal masticatory muscle morphology ( J:111337 )

• most double homozygotes show a complete absence of the major muscles of mastication, not observed in either single homozygote

absent masseter muscle ( J:111337 )

• most double homozygotes show a complete absence of the masseter muscle

abnormal pterygoid muscle morphology ( J:111337 )

• atrophic pterygoid myofibers are found to persist unilaterally in a subset of double homozygotes

absent pterygoid muscle ( J:111337 )

• most double homozygotes show a complete absence of the medial and lateral pterygoid muscles

absent temporalis muscle ( J:111337 )

• most double homozygotes show a complete absence of the temporalis muscle

cleft secondary palate ( J:111337 )

• double homozygotes exhibit cleft palate

abnormal palatal shelf elevation ( J:111337 )

• palatal shelves do not elevate or elevate unilaterally (Fig. 3c)

digestive/alimentary system

cleft secondary palate ( J:111337 )

• double homozygotes exhibit cleft palate

abnormal palatal shelf elevation ( J:111337 )

• palatal shelves do not elevate or elevate unilaterally (Fig. 3c)

growth/size/body

abnormal masticatory muscle morphology ( J:111337 )

• most double homozygotes show a complete absence of the major muscles of mastication, not observed in either single homozygote

absent masseter muscle ( J:111337 )

• most double homozygotes show a complete absence of the masseter muscle

abnormal pterygoid muscle morphology ( J:111337 )

• atrophic pterygoid myofibers are found to persist unilaterally in a subset of double homozygotes

absent pterygoid muscle ( J:111337 )

• most double homozygotes show a complete absence of the medial and lateral pterygoid muscles

absent temporalis muscle ( J:111337 )

• most double homozygotes show a complete absence of the temporalis muscle

cleft secondary palate ( J:111337 )

• double homozygotes exhibit cleft palate

abnormal palatal shelf elevation ( J:111337 )

• palatal shelves do not elevate or elevate unilaterally (Fig. 3c)

Allelic Composition	Msc^tm1Eno/Msc⁺ Tcf21^tm2Eno/Tcf21^tm2Eno
Genetic Background	involves: 129 * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msc^tm1Eno mutation (1 available); any Msc mutation (11 available)
Tcf21^tm2Eno mutation (0 available); any Tcf21 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

muscle phenotype ( J:111337 )

N	• unlike double homozygotes, mice heterozygous for Msc^tm1Eno and homozygous for Tcf21^tm2Eno exhibit no morphological defects in first branchial arch-derived masticatory skeletal muscles

Allelic Composition	Msc^tm1Eno/Msc^tm1Eno Tcf21^tm2Eno/Tcf21⁺
Genetic Background	involves: 129 * Black Swiss

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:111337 )

• unlike double homozygotes, mice homozygous for Msc^tm1Eno and heterozygous for Tcf21^tm2Eno are viable and exhibit no morphological defects in first branchial arch-derived masticatory skeletal muscles

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23