Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja1tm1.1Gfi mutation
(0 available);
any
Gja1 mutation
(59 available)
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mortality/aging
cardiovascular system
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• exhibit exaggerated right ventricular trabeculation
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• exhibit misshapen right ventricle outflow tracts with large infundibular bulges
• outflow tracts appear dilated and more densely trabeculated
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• large infundibular bulges; the infundibular myocardium begins to bulge above the plane of the pulmonic valve at E15.5
• regions of the infundibular wall show thinning
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• the right ventricular wall is slightly thinner
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nervous system
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• exhibit a late phase of cellular delamination from the dorsal and lateral neural tube
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muscle
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• exhibit exaggerated right ventricular trabeculation
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Allelic
Composition |
Gja1tm1.1Gfi/Gja1+
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Genetic
Background |
Not Specified |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja1tm1.1Gfi mutation
(0 available);
any
Gja1 mutation
(59 available)
|
|
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cardiovascular system
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• 2 of 5 mutants exhibit myocardial and septal coronary arteries originating from the same ostium on the aorta, rather than branching from a main coronary artery
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja1tm1.1Gfi mutation
(0 available);
any
Gja1 mutation
(59 available)
Gja1tm1Gfi mutation
(0 available);
any
Gja1 mutation
(59 available)
Tg(Pax3-cre)1Joe mutation
(0 available)
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mortality/aging
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• partial postnatal lethality, as only 4.6% of pups at 2 weeks of age are mutants
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growth/size/body
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• neonatal weights are decreased by 11.6%
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cardiovascular system
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• 3 of 5 neonates exhibit a variety of coronary abnormalities
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• the right ventricle appears more heavily trabeculated at E15.5
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• exhibit a late phase of cellular delamination from the dorsal and lateral neural tube, a markedly increased abundance of neuroepithelium-derived cells outside of the neural tube and an excess of such cells infiltrating the heart and infundibulum
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• neonates exhibit grossly misshapen right ventricle outflow tract (RVOT), with large infundibular bulges seen bilaterally flanking the outflow tract
• RVOT is first observed at E15.5, with the right ventricle appearing more heavily trabeculated
• outflow tracts appear dilated and more densly trabeculated
• regions of the infundibular wall showing thinning
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• the right ventricular wall is slightly thinner
|
nervous system
|
|
• exhibit a late phase of cellular delamination from the dorsal and lateral neural tube, a markedly increased abundance of neuroepithelium-derived cells outside of the neural tube and an excess of such cells infiltrating the heart and infundibulum
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muscle
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• the right ventricle appears more heavily trabeculated at E15.5
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Analysis Tools