Phenotypes associated with this allele
Allelic
Composition |
Fli1tm1Ber/Fli1tm1Ber
|
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Genetic
Background |
either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fli1tm1Ber mutation
(0 available);
any
Fli1 mutation
(26 available)
|
|
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hematopoietic system
|
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• thymocyte numbers are decreased by 30-50% compared to control mice
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immune system
|
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• thymocyte numbers are decreased by 30-50% compared to control mice
|
endocrine/exocrine glands
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• thymocyte numbers are decreased by 30-50% compared to control mice
|
Allelic
Composition |
Fli1tm1Ber/Fli1tm1Ber
|
|
Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fli1tm1Ber mutation
(0 available);
any
Fli1 mutation
(26 available)
|
|
|
immune system
|
|
• mice develop splenomegaly a characteristic of Friend leukemia
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hematopoietic system
|
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• mice develop splenomegaly a characteristic of Friend leukemia
|
|
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• mice develop severe anemia leading to lethality characteristic of Friend leukemia
|
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• infected null mice show decreased hematocrits around day 55 while in wild-type, hematocrits start to drop around day 40
|
neoplasm
|
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• null mice for Fli1 from matings of heterozygous animals infected with F-MuLV at birth develop but the disease has a consistently longer latency period than littermate controls
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growth/size/body
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• mice develop splenomegaly a characteristic of Friend leukemia
|
Allelic
Composition |
Fli1tm1Ber/Fli1+
|
|
Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fli1tm1Ber mutation
(0 available);
any
Fli1 mutation
(26 available)
|
|
|
neoplasm
|
|
• latency period falls between infected homozygous animals and that of infected wild-type
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Analysis Tools