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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rcan2tm1Jmol
targeted mutation 1, Jeffery D Molkentin
MGI:3641543
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Rcan1tm1Jmol/Rcan1tm1Jmol
Rcan2tm1Jmol/Rcan2tm1Jmol 		involves: 129 * C57BL/6 MGI:3652924
cx2
 		Rcan2tm1Jmol/Rcan2tm1Jmol
Tg(Myh6-Ppp3ca)37Eno/0 		involves: 129 * C57BL/6 * FVB MGI:3652922
cx3
 		Rcan1tm1Jmol/Rcan1tm1Jmol
Rcan2tm1Jmol/Rcan2tm1Jmol
Ppp3cbtm1Jmk/Ppp3cbtm1Jmk 		involves: 129S6/SvEvTac * C57BL/6 MGI:3652928


Genotype
MGI:3652924
cx1
Allelic
Composition		 Rcan1tm1Jmol/Rcan1tm1Jmol
Rcan2tm1Jmol/Rcan2tm1Jmol
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rcan1tm1Jmol mutation (1 available); any Rcan1 mutation (24 available)
Rcan2tm1Jmol mutation (1 available); any Rcan2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal object recognition memory ( J:109586 )
• mice show subtle but significant impairment in working memory assessed by novel and familiar object recognition
hyperactivity ( J:109586 )
• mice show a significant increase in cumulative activity during light and dark conditions

immune system
decreased T cell proliferation ( J:109586 )
• in response to stimulation, total splenocytes show reduced proliferation
abnormal CD4-positive, alpha-beta T cell physiology ( J:109586 )
• after CD3 stimulation, increased apoptosis of CD4+ T cells is observed
abnormal cytokine secretion ( J:109586 )
• in response to stimulation, total splenocytes show reduced proliferation and Il2 production compared to wild-type

cardiovascular system
abnormal myocardium layer morphology ( J:109586 )
• mice do not display cardiac hypertrophy in response to 2 weeks of infusion of phenylephrine plus angiotensin II or 3 weeks of forced exercise unlike wild-type mice
decreased response of heart to induced stress ( J:109586 )
• cardiac function reveals partial protection from pressure overload stimulation decompensation induced by transverse aortic constriction compared to wild-type; cardiac hypertrophy is attenuated
abnormal response to cardiac infarction ( J:109586 )
• myocardial damage is increased in mice after ischemia-reperfusion injury

hematopoietic system
decreased T cell proliferation ( J:109586 )
• in response to stimulation, total splenocytes show reduced proliferation
abnormal CD4-positive, alpha-beta T cell physiology ( J:109586 )
• after CD3 stimulation, increased apoptosis of CD4+ T cells is observed

homeostasis/metabolism
decreased response of heart to induced stress ( J:109586 )
• cardiac function reveals partial protection from pressure overload stimulation decompensation induced by transverse aortic constriction compared to wild-type; cardiac hypertrophy is attenuated
abnormal response to cardiac infarction ( J:109586 )
• myocardial damage is increased in mice after ischemia-reperfusion injury

cellular
decreased T cell proliferation ( J:109586 )
• in response to stimulation, total splenocytes show reduced proliferation

muscle
abnormal myocardium layer morphology ( J:109586 )
• mice do not display cardiac hypertrophy in response to 2 weeks of infusion of phenylephrine plus angiotensin II or 3 weeks of forced exercise unlike wild-type mice




Genotype
MGI:3652922
cx2
Allelic
Composition		 Rcan2tm1Jmol/Rcan2tm1Jmol
Tg(Myh6-Ppp3ca)37Eno/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rcan2tm1Jmol mutation (1 available); any Rcan2 mutation (26 available)
Tg(Myh6-Ppp3ca)37Eno mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased heart weight ( J:109586 )
• at 3 weeks of age, transgenic mice display a ~2-fold increase in heart weight to tibia length ratio compared to non transgenic mice

growth/size/body
increased heart weight ( J:109586 )
• at 3 weeks of age, transgenic mice display a ~2-fold increase in heart weight to tibia length ratio compared to non transgenic mice




Genotype
MGI:3652928
cx3
Allelic
Composition		 Rcan1tm1Jmol/Rcan1tm1Jmol
Rcan2tm1Jmol/Rcan2tm1Jmol
Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3cbtm1Jmk mutation (1 available); any Ppp3cb mutation (66 available)
Rcan1tm1Jmol mutation (1 available); any Rcan1 mutation (24 available)
Rcan2tm1Jmol mutation (1 available); any Rcan2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
hyperactivity ( J:109586 )
• mice show a significant increase in cumulative activity during light and dark conditions, even greater than that shown in Dscr1/Dscr1l1 knockouts

immune system
decreased T cell proliferation ( J:109586 )
• in response to stimulation, total splenocytes show reduced proliferation
abnormal CD4-positive, alpha beta T cell morphology ( J:109586 )
• T cell development is compromised in triple knockouts compared to wild-type, single or double knockouts; a reduction in number in the spleen is observed
abnormal CD8-positive, alpha beta T cell morphology ( J:109586 )
• T cell development is compromised in triple knockouts compared to wild-type, single or double knockouts; a reduction in number in the spleen is observed
abnormal CD4-positive, alpha-beta T cell physiology ( J:109586 )
• after CD3 stimulation, increased apoptosis of CD4+ T cells is observed
abnormal cytokine secretion ( J:109586 )
• in response to stimulation, total splenocytes show increased Il2 production compared to wild-type

hematopoietic system
decreased T cell proliferation ( J:109586 )
• in response to stimulation, total splenocytes show reduced proliferation
abnormal CD4-positive, alpha beta T cell morphology ( J:109586 )
• T cell development is compromised in triple knockouts compared to wild-type, single or double knockouts; a reduction in number in the spleen is observed
abnormal CD8-positive, alpha beta T cell morphology ( J:109586 )
• T cell development is compromised in triple knockouts compared to wild-type, single or double knockouts; a reduction in number in the spleen is observed
abnormal CD4-positive, alpha-beta T cell physiology ( J:109586 )
• after CD3 stimulation, increased apoptosis of CD4+ T cells is observed

cardiovascular system
decreased response of heart to induced stress ( J:109586 )
• cardiac function reveals partial protection from pressure overload stimulation decompensation induced by transverse aortic constriction compared to wild-type; cardiac hypertrophy is attenuated

homeostasis/metabolism
decreased response of heart to induced stress ( J:109586 )
• cardiac function reveals partial protection from pressure overload stimulation decompensation induced by transverse aortic constriction compared to wild-type; cardiac hypertrophy is attenuated

cellular
decreased T cell proliferation ( J:109586 )
• in response to stimulation, total splenocytes show reduced proliferation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory