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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sh2d1b1tm1Vei
targeted mutation 1, Andre Veillette
MGI:3641174
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sh2d1b1tm1Vei/Sh2d1b1tm1Vei involves: 129S1/Sv * 129X1/SvJ MGI:3641454


Genotype
MGI:3641454
hm1
Allelic
Composition		 Sh2d1b1tm1Vei/Sh2d1b1tm1Vei
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1b1tm1Vei mutation (0 available); any Sh2d1b1 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased natural killer cell mediated cytotoxicity ( J:110195 )
• Il2-activated NK cells have an increased ability to kill target cells like CHO and YB cells in vitro
increased interferon-gamma secretion ( J:110195 )
• Il2-activated NK cells produce a 4- to 5-fold increase in receptor-mediated Ifng production in vitro

hematopoietic system
increased natural killer cell mediated cytotoxicity ( J:110195 )
• Il2-activated NK cells have an increased ability to kill target cells like CHO and YB cells in vitro




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory