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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Csn3tm1Kuma
targeted mutation 1, Satish Kumar
MGI:3640309
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Csn3tm1Kuma/Csn3tm1Kuma involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3640310
ht2
Csn3tm1Kuma/Csn3+ involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3640311


Genotype
MGI:3640310
hm1
Allelic
Composition
Csn3tm1Kuma/Csn3tm1Kuma
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csn3tm1Kuma mutation (0 available); any Csn3 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• mammary gland morphology is normal but protein aggregates are found in the alveolar lumina, these appear to be the result of coagulation and retention of secreted caseins
• failure of lactation; however, both sexes are fertile and females can carry pups to term
• when injected with oxytocin females produce no milk but do produce very small volumes of a yellowish secretion

integument
• mammary gland morphology is normal but protein aggregates are found in the alveolar lumina, these appear to be the result of coagulation and retention of secreted caseins
• failure of lactation; however, both sexes are fertile and females can carry pups to term
• when injected with oxytocin females produce no milk but do produce very small volumes of a yellowish secretion




Genotype
MGI:3640311
ht2
Allelic
Composition
Csn3tm1Kuma/Csn3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csn3tm1Kuma mutation (0 available); any Csn3 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• abnormal coalescence of micelles in defatted milk

integument
• abnormal coalescence of micelles in defatted milk





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory