Mouse Genome Informatics
hm1
    Ddr2slie/Ddr2slie
BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpefat/LtJng
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• 15% of homozygotes die before 3 months of age and 47% die by 6 months

endocrine/exocrine glands
• proportion of pituitary gland area to whole brain area is reduced as compared to wildtype at 4 weeks, however, size difference disappears by adulthood
• corpora lutea is absent in 6 week old and 4 month old females, however, pre-antral, antral and Graffian follicles appear normal (J:134371)

growth/size
• significant decrease in percentage of body fat at 5-6 months as compared to wildtype
• snub nose is visible by four months of age
• significant increase in percentage of lean mass at 5-6 months as compared to wildtype
• after weaning weight gain is slower than wildtype
• homozygotes do not exhibit juvenile growth spurt

adipose tissue
• significant decrease in percentage of body fat at 5-6 months as compared to wildtype

craniofacial
• snub nose is visible by four months of age

homeostasis/metabolism
• following injection of exogenous gonadotropin in 12-14 week old mice, testosterone levels are lower than adult wildtype and similar to prepubertal wildtype
• following injection of exogenous gonadotropin in 12-14 week old mice, estradiol levels are lower than adult wildtype and similar to prepubertal wildtype
• following injection of exogenous gonadotropin in 12-14 week old mice, progesterone levels are lower than adult wildtype and similar to prepubertal wildtype

vision/eye
• protuberant eyes are observed by four months of age

skeleton
• bone mineral content is reduced in comparison to wildtype, however density is not reduced

reproductive system
• atrophy is observed in spermatogonia, Leydig and Serotoli cells at 4 months (J:134371)
• corpora lutea is absent in 6 week old and 4 month old females, however, pre-antral, antral and Graffian follicles appear normal (J:134371)
• following injection of exogenous gonadotropin in 12-14 week old mice, vaginal opening is observed in 100% of prepubertal wildtype and 80% of adult homozygotes, however, the condition is pre-existing in wildtype 12-14 week old mice (J:134371)
• number of spermatids is reduced in 4 month old mice, but not in 6 week old mice (J:134371)
• females are anovulatory (J:134371)
• following injection of PMSG and hCG at 6 weeks follicular growth to the Graffian stage is induced, but, full luteinization of thecal cells does not occur (J:134371)
• female homozygote matings to wildtype fail to produce offspring (J:134371)
• occasionally homozygote males crossed to heterozygote or wildtype females produce offspring (J:134371)

nervous system
• proportion of pituitary gland area to whole brain area is reduced as compared to wildtype at 4 weeks, however, size difference disappears by adulthood

cellular
• atrophy is observed in spermatogonia, Leydig and Serotoli cells at 4 months (J:134371)

Mouse Models of Human Disease
OMIM IDRef(s)
Dwarfism, Levi Type 127100 J:134371