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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Msntm1Sts
targeted mutation 1, Shoichiro Tsukita
MGI:3630284
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Msntm1Sts/Msntm1Sts involves: 129S4/SvJae * C57BL/6 MGI:3630285
ot2
Msntm1Sts/Y involves: 129S4/SvJae * C57BL/6 MGI:3630286


Genotype
MGI:3630285
hm1
Allelic
Composition
Msntm1Sts/Msntm1Sts
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msntm1Sts mutation (0 available); any Msn mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice develop normally and are fertile
• no obvious histological abnormalities are seen
• function of platelets, fibroblasts and mast cells appears similar to controls




Genotype
MGI:3630286
ot2
Allelic
Composition
Msntm1Sts/Y
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msntm1Sts mutation (0 available); any Msn mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• T cell egress from the thymus and immature B cell egress from the BM is impaired
• T and B cells showed delayed egress from lymphoid organs

hematopoietic system
• T cell egress from the thymus and immature B cell egress from the BM is impaired
• T and B cells showed delayed egress from lymphoid organs
• reduction in the total leukocyte count, to 43% of the level in littermate controls
• number of cells was decreased in all leukocyte subsets examined, except for the Gr-1+ monocyte subset
• in lymph nodes but not in spleen

homeostasis/metabolism
• weight loss and increased mortality of male mutant mice is seen upon treatment with bleomycin
• severe lung injury upon bleomycin treatment is seen in male mutant mice compared with controls

immune system
• T cell egress from the thymus and immature B cell egress from the BM is impaired
• T and B cells showed delayed egress from lymphoid organs
• reduction in the total leukocyte count, to 43% of the level in littermate controls
• number of cells was decreased in all leukocyte subsets examined, except for the Gr-1+ monocyte subset
• in lymph nodes but not in spleen

respiratory system
• a significant increase in the size of the distal alveoli is seen in male mutant mice compared with controls
• the air spaces of untreated adult male mutant mice are markedly enlarged, without signs of inflammation or alveolar destruction

normal phenotype
• mice develop normally and are fertile
• no obvious histological abnormalities are seen
• function of platelets, fibroblasts and mast cells appears similar to controls





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory