All Phenotypes Ptgs2<tm1.1Fun> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ptgs2^tm1.1Fun
targeted mutation 1.1, Colin D Funk
MGI:3629677

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptgs2^tm1.1Fun/Ptgs2^tm1.1Fun	involves: 129S6/SvEvTac	MGI:3846764
hm2	Ptgs2^tm1.1Fun/Ptgs2^tm1.1Fun	involves: 129S6/SvEvTac * C57BL/6	MGI:3629784
cx3	Ptgs1^tm1Unc/Ptgs1^tm1Unc Ptgs2^tm1.1Fun/Ptgs2^tm1.1Fun	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	MGI:3629785

Allelic Composition	Ptgs2^tm1.1Fun/Ptgs2^tm1.1Fun
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs2^tm1.1Fun mutation (1 available); any Ptgs2 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

kidney inflammation ( J:148699 )

• moderate interstitial inflammation

abnormal kidney cortex morphology ( J:148699 )

• almost complete loss of the cortical mantle

• display atrophic cortices

glomerulosclerosis ( J:148699 )

• mild to moderate

decreased renal glomerulus number ( J:148699 )

• hypoplastic glomeruli

homeostasis/metabolism

increased blood urea nitrogen level ( J:148699 )

immune system

kidney inflammation ( J:148699 )

• moderate interstitial inflammation

Allelic Composition	Ptgs2^tm1.1Fun/Ptgs2^tm1.1Fun
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs2^tm1.1Fun mutation (1 available); any Ptgs2 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal kidney cortex morphology ( J:109548 )

• atrophic

abnormal renal glomerulus morphology ( J:109548 )

• hypoplastic

glomerulosclerosis ( J:109548 )

• moderate

small kidney ( J:109548 )

pale kidney ( J:109548 )

reproductive system

reduced female fertility ( J:109548 )

• number of term pregnancies reduced

homeostasis/metabolism

decreased prostaglandin level ( J:109548 )

• near absence of LPS induced synthesis

Allelic Composition	Ptgs1^tm1Unc/Ptgs1^tm1Unc Ptgs2^tm1.1Fun/Ptgs2^tm1.1Fun
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs1^tm1Unc mutation (0 available); any Ptgs1 mutation (44 available)
Ptgs2^tm1.1Fun mutation (1 available); any Ptgs2 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:109548 )

• all die within the first day of life

cardiovascular system

patent ductus arteriosus ( J:109548 )

cellular

patent ductus arteriosus ( J:109548 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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