About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sohlh1tm1Rajk
targeted mutation 1, Aleksandar Rajkovic
MGI:3629211
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sohlh1tm1Rajk/Sohlh1tm1Rajk involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6 MGI:5817765
hm2
 		Sohlh1tm1Rajk/Sohlh1tm1Rajk involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 MGI:3630148


Genotype
MGI:5817765
hm1
Allelic
Composition		 Sohlh1tm1Rajk/Sohlh1tm1Rajk
Genetic
Background		 involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sohlh1tm1Rajk mutation (1 available); any Sohlh1 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
absent primary ovarian follicles ( J:110210 )
• ovaries lack primary follicles at P3
absent ovarian follicles ( J:110210 )
• ovaries beyond 7 weeks of age lack follicular structures
impaired ovarian folliculogenesis ( J:110210 )
• ovarian follicle development appears to be impaired during the primordial-to-primary follicle transition
• fewer advanced follicle types and empty follicles are observed at P7 with no oocytes remaining by 3 weeks of age
ovary atrophy ( J:110210 )
• ovaries are significantly smaller at P7 and atrophic by 10 weeks of age
• adult ovaries occupy only ~1/10 of wild-type volume
• however, newborn ovaries show normal morphology and histology
decreased oocyte number ( J:110210 )
• ovaries contain few germ cells by 3 weeks of age
• however, newborn ovaries show a normal number of oocytes within germ cell clusters and primordial follicles
absent oocytes ( J:110210 )
• ovaries beyond 7 weeks of age lack germ cells
female infertility ( J:110210 )
• all females are infertile

cellular
decreased oocyte number ( J:110210 )
• ovaries contain few germ cells by 3 weeks of age
• however, newborn ovaries show a normal number of oocytes within germ cell clusters and primordial follicles
absent oocytes ( J:110210 )
• ovaries beyond 7 weeks of age lack germ cells

endocrine/exocrine glands
absent primary ovarian follicles ( J:110210 )
• ovaries lack primary follicles at P3
absent ovarian follicles ( J:110210 )
• ovaries beyond 7 weeks of age lack follicular structures
impaired ovarian folliculogenesis ( J:110210 )
• ovarian follicle development appears to be impaired during the primordial-to-primary follicle transition
• fewer advanced follicle types and empty follicles are observed at P7 with no oocytes remaining by 3 weeks of age
ovary atrophy ( J:110210 )
• ovaries are significantly smaller at P7 and atrophic by 10 weeks of age
• adult ovaries occupy only ~1/10 of wild-type volume
• however, newborn ovaries show normal morphology and histology




Genotype
MGI:3630148
hm2
Allelic
Composition		 Sohlh1tm1Rajk/Sohlh1tm1Rajk
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sohlh1tm1Rajk mutation (1 available); any Sohlh1 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:109310 )
• at 7 weeks of age, seminiferous tubules are hypocellular with clumps of Sertoli cells in the lumen
decreased testis weight ( J:109310 )
• at 3 weeks of age testes from homozygotes weigh ~one half that of wild-type or heterozygous testes; in adults, testes weighed 3.5-fold less than wild-type

reproductive system
abnormal seminiferous tubule morphology ( J:109310 )
• at 7 weeks of age, seminiferous tubules are hypocellular with clumps of Sertoli cells in the lumen
decreased testis weight ( J:109310 )
• at 3 weeks of age testes from homozygotes weigh ~one half that of wild-type or heterozygous testes; in adults, testes weighed 3.5-fold less than wild-type
abnormal spermatogenesis ( J:109310 )
• at 10 days of age, 90% of testes tubules do not contain spermatocytes; at 2 weeks, 65% of tubules do not contain spermatocytes and at 7 weeks tubules are devoid of spermatocytes
• in 8 month old males spermatogonia stem cells continue to proliferate but cannot differentiate into mature spermatocytes
male infertility ( J:109310 )
• males are infertile due to defective spermatogonial differentiation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory